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青少年高血压膳食防治计划(DASH)饮食与胃食管反流病的相关性。

Dietary approaches to stop hypertension (DASH)-style diet in association with gastroesophageal reflux disease in adolescents.

机构信息

Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

出版信息

BMC Public Health. 2023 Feb 17;23(1):358. doi: 10.1186/s12889-023-15225-6.

DOI:10.1186/s12889-023-15225-6
PMID:36803489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9936743/
Abstract

BACKGROUND

Dietary patterns and food items have been associated with gastroesophageal reflux disease (GERD) risk and they have led to conflicting findings. The aim of this study was to determine the association between a dietary approach to stop hypertension (DASH)-style diet with the risk of GERD and its symptoms in adolescents.

STUDY DESIGN

Cross-sectional.

METHODS

This study was performed on 5,141 adolescents aged between 13 and 14 years. Dietary intake was evaluated using a food frequency method. The diagnosis of GERD was done by using a six-item GERD questionnaire that asked about GERD symptoms. A binary logistic regression was used to assess the association between the DASH-style diet score and GERD and its symptoms in crude and multivariable-adjusted models.

RESULTS

Our findings revealed that after adjustment for all confounding variables, the adolescents with the highest adherence to the DASH-style diet had a lower chance of developing GERD [odds ratio (OR) = 0.50; 95%CI 0.33-0.75, P< 0.001)], reflux (OR = 0.42; 95%CI 0.25-0.71, P=0.001), nausea (OR = 0.59; 95% CI:0.32-1.08, P=0.05) and stomach pain (OR = 0.69; 95%CI 0.49-0.98, P =0.03) compared to those with the lowest adherence. Similar results were found for odds of GERD among boys, and the total population (OR = 0.37; 95%CI: 0.18-0.73, P=0.002, OR = 0.51; 95%CI: 0.34-0.77, P <0.0, respectively).

CONCLUSION

The current study revealed that adherence to a DASH-style diet might protect against GERD and its symptoms including, reflux, nausea, and stomach pain in adolescents. Further prospective research is needed to confirm these findings.

摘要

背景

饮食模式和食物与胃食管反流病(GERD)风险相关,且已有研究结果存在冲突。本研究旨在确定 DASH 饮食与青少年 GERD 风险及其症状之间的关系。

研究设计

横断面研究。

方法

本研究纳入了 5141 名年龄在 13-14 岁的青少年。采用食物频率法评估饮食摄入情况。使用六分量表 GERD 问卷诊断 GERD,问卷询问 GERD 症状。采用二元逻辑回归分析评估 DASH 饮食评分与 GERD 及其症状之间的关系,模型分为未校正和校正混杂因素两种。

结果

调整所有混杂因素后,我们发现,最遵循 DASH 饮食模式的青少年发生 GERD 的可能性较低[比值比(OR)=0.50;95%可信区间(CI)0.33-0.75,P<0.001]、反流(OR=0.42;95%CI 0.25-0.71,P=0.001)、恶心(OR=0.59;95%CI 0.32-1.08,P=0.05)和胃痛(OR=0.69;95%CI 0.49-0.98,P=0.03)的可能性均较低。对于男性和总体人群,GERD 风险的 OR 也存在类似的结果(OR=0.37;95%CI:0.18-0.73,P=0.002,OR=0.51;95%CI:0.34-0.77,P<0.0)。

结论

本研究表明,遵循 DASH 饮食模式可能有助于预防青少年 GERD 及其症状,包括反流、恶心和胃痛。需要进一步的前瞻性研究来证实这些发现。

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