School of Physics, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand.
Department of Engineering, School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom.
SLAS Technol. 2023 Jun;28(3):127-141. doi: 10.1016/j.slast.2023.02.002. Epub 2023 Feb 17.
Cancer is a critical cause of global human death. Not only are complex approaches to cancer prognosis, accurate diagnosis, and efficient therapeutics concerned, but post-treatments like postsurgical or chemotherapeutical effects are also followed up. The four-dimensional (4D) printing technique has gained attention for its potential applications in cancer therapeutics. It is the next generation of the three-dimensional (3D) printing technique, which facilitates the advanced fabrication of dynamic constructs like programmable shapes, controllable locomotion, and on-demand functions. As is well-known, it is still in the initial stage of cancer applications and requires the insight study of 4D printing. Herein, we present the first effort to report on 4D printing technology in cancer therapeutics. This review will illustrate the mechanisms used to induce the dynamic constructs of 4D printing in cancer management. The recent potential applications of 4D printing in cancer therapeutics will be further detailed, and future perspectives and conclusions will finally be proposed.
癌症是全球人类死亡的一个重要原因。不仅需要关注癌症预后、准确诊断和有效治疗的复杂方法，还需要跟踪治疗后的效果，如手术后或化疗后的效果。四维（4D）打印技术因其在癌症治疗中的潜在应用而受到关注。它是三维（3D）打印技术的下一代，可以促进可编程形状、可控运动和按需功能等动态结构的先进制造。众所周知，它仍处于癌症应用的初始阶段，需要深入研究 4D 打印。在这里，我们首次努力报告 4D 打印技术在癌症治疗中的应用。本综述将说明用于诱导癌症管理中 4D 打印动态结构的机制。还将进一步详细介绍 4D 打印在癌症治疗中的最新潜在应用，并最终提出未来的观点和结论。
