肽 O⋯HN 氢键的特征：H 检测的 N/O 固态 NMR 光谱学。
Characterization of peptide O⋯HN hydrogen bonds H-detected N/O solid-state NMR spectroscopy.
机构信息
National High Magnetic Field Laboratory, 1800 East Paul Dirac Drive, Tallahassee, Florida, 32310, USA.
Department of Chemistry and Francis Bitter Magnet Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA.
出版信息
Chem Commun (Camb). 2023 Mar 9;59(21):3111-3113. doi: 10.1039/d2cc07004a.
High sensitivity and resolution solid-state NMR methods are reported, that straightforwardly select hydrogen-bonded N-O pairs from amongst all other nitrogen and oxygen sites in peptides, to aid protein secondary and tertiary structure determination. Significantly improved sensitivity is obtained with indirect H detection under fast MAS and stronger relayed dipole couplings.
报道了高灵敏度和分辨率的固态 NMR 方法，该方法可以直接从肽中的所有其他氮和氧位点中选择氢键结合的 N-O 对，以辅助蛋白质二级和三级结构的测定。在快速 MAS 和更强的接力偶极耦合下，通过间接 H 检测可获得显著提高的灵敏度。
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