基于槐糖脂的微乳递送系统：对黄腐酚物理化学性质的多方面增强

Sophorolipid-based microemulsion delivery system: Multifaceted enhancement of physicochemical properties of xanthohumol.

作者信息

Luo Jingyang, Yang Bowen, Yang Xiaoling, Ji Shengyang, Guo Zefeng, Liu Yan, Chen Qi, Zhao Tian, Wang Yixuan, Lu Baiyi

机构信息

College of Biosystems Engineering and Food Science, Key Laboratory for Quality Evaluation and Health Benefit of Agro-Products of Ministry of Agriculture and Rural Affairs, Key Laboratory for Quality and Safety Risk Assessment of Agro-Products Storage and Preservation of Ministry of Agriculture and Rural Affairs, Zhejiang University, Hangzhou 310058, China; Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou, 311200, China.

Hangzhou Qiandao Lake Beer Company Limited, Hangzhou 311700, China.

出版信息

Food Chem. 2023 Jul 1;413:135631. doi: 10.1016/j.foodchem.2023.135631. Epub 2023 Feb 3.

DOI:10.1016/j.foodchem.2023.135631

PMID:36804741

Abstract

Xanthohumol (XN) has numerous compelling physiological activities, but the poor solubility and stability severely limit its utilization. Therefore, a microemulsion (ME) delivery system based on biosurfactant sophorolipids (SLs) was established and its improvement on physicochemical properties of XN was investigated. The results showed that the systems increased the solubility of XN by about 4000 times, and its half-life during storage was extended to over 150 days. Partial replacement of Tween 80 with SL did not greatly affect their ability to form O/W subregions (in the high aqueous phase), but further improved the solubilization efficiency, storage stability, and antioxidant properties of XN. In vitro models revealed the release profile of XN from the systems followed non-Fickian diffusion, and the ME structure markedly strengthened its digestive stability and bioaccessibility. These results indicated that SL-based ME systems had great potential as a green solubilization and delivery method for XN and other hydrophobic drugs.

摘要

黄腐酚（XN）具有众多引人注目的生理活性，但其溶解性和稳定性较差，严重限制了其应用。因此，建立了一种基于生物表面活性剂槐糖脂（SLs）的微乳（ME）递送系统，并研究了其对XN理化性质的改善作用。结果表明，该系统使XN的溶解度提高了约4000倍，其储存半衰期延长至150多天。用SL部分替代吐温80对其形成水包油亚区域（在高水相）的能力影响不大，但进一步提高了XN的增溶效率、储存稳定性和抗氧化性能。体外模型显示，XN从该系统中的释放曲线遵循非菲克扩散，且ME结构显著增强了其消化稳定性和生物可及性。这些结果表明，基于SL的ME系统作为XN和其他疏水药物的绿色增溶和递送方法具有巨大潜力。