Liu Yongchun, Li Wei, Wu Keyue, Lei Bingfu, Chen Jianying, Zhang Xiaoyong, Lei Hongtao, Duan Xuewu, Huang Riming
University Joint Laboratory of Guangdong Province, Hong Kong and Macao Region on Marine Bioresource Conservation and Exploitation, College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China.
Key Laboratory for Biobased Materials and Energy of Ministry of Education, College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Food Chem. 2023 Jul 1;413:135687. doi: 10.1016/j.foodchem.2023.135687. Epub 2023 Feb 11.
It is urgent to develop high-efficiency and low-toxicity natural antifungal agents on green mold caused by Penicillium digitatum. The effect of 2-methoxy-1, 4-naphthoquinone (MNQ) inhibition of P. digitatum was not very satisfactory. MNQ-derived carbon dots (MNQ-CDs) synthesized through a solvothermal route were used as antifungal agents against P. digitatum. The antifungal activity of prepared MNQ-CDswas enhanced compared to MNQ, and the minimum inhibitory concentration was 2.8 μg/mL. A total of 441 genes and 122 metabolites have undergone significant changes. The omics data revealed that MNQ-CDs primarily modified the metabolism of aromatic amino acids and synthesis of the cell membrane in P. digitatum, thereby inhibiting its propagation. Furthermore, compared with MNQ, MNQ-CDs had a better control effect on the green mold of citrus fruits, and could more significantly inhibit the propagation of P. digitatum. This study provides a new idea for the design of new and efficient antifungal materials.
开发针对指状青霉引起的绿霉病的高效低毒天然抗真菌剂迫在眉睫。2-甲氧基-1,4-萘醌（MNQ）对指状青霉的抑制效果不太理想。通过溶剂热法合成的MNQ衍生碳点（MNQ-CDs）被用作抗指状青霉的抗真菌剂。制备的MNQ-CDs的抗真菌活性比MNQ有所增强，最低抑菌浓度为2.8μg/mL。共有441个基因和122种代谢物发生了显著变化。组学数据表明，MNQ-CDs主要改变了指状青霉中芳香族氨基酸的代谢和细胞膜的合成，从而抑制其繁殖。此外，与MNQ相比，MNQ-CDs对柑橘类水果的绿霉病有更好的防治效果，能更显著地抑制指状青霉的繁殖。本研究为新型高效抗真菌材料的设计提供了新思路。
