Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
International Joint Research Center for Photo-responsive Molecules and Materials, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Chem Commun (Camb). 2023 Mar 7;59(20):2974-2977. doi: 10.1039/d2cc05550c.
A near-infrared fluorescent nanoprobe based on semiconducting polymer nanoparticles (SPNs) for the detection of senescence-associated β-gal (SA-β-gal) is developed. Benefiting from the intrinsic lysosome-locating feature, this probe can be successfully used for the visualization of SA-β-gal in living cells.
开发了一种基于半导体聚合物纳米粒子（SPNs）的近红外荧光纳米探针，用于检测衰老相关β-半乳糖苷酶（SA-β-gal）。得益于内在的溶酶体定位特性，该探针可成功用于活细胞中 SA-β-gal 的可视化。
