Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Science, Beijing, 100190, China.
Faculty of Chemistry and Biochemistry, Ruhr University Bochum, Universitätsstrasse 150, 44780, Bochum, Germany.
Angew Chem Int Ed Engl. 2023 May 15;62(21):e202300662. doi: 10.1002/anie.202300662. Epub 2023 Mar 8.
Cancer is one of the deadliest diseases worldwide. Recent statistics have shown that metastases and tumor relapse are the leading causes of cancer-associated deaths. While traditional treatments are able to efficiently remove the primary tumor, secondary tumors remain poorly accessible. Capitalizing on this there is an urgent need for novel treatment modalities. Among the most promising approaches, increasing research interest has been devoted to immunogenic cell death inducing agents that are able to trigger localized cell death of the cancer cells as well as induce an immune response inside the whole organism. Preliminary studies have shown that immunogenic cell death inducing compounds could be able to overcome metastatic and relapsing tumors. Herein, the application of metal complexes as immunogenic cell death inducing compounds is systematically reviewed.
癌症是全球最致命的疾病之一。最近的统计数据表明，转移和肿瘤复发是癌症相关死亡的主要原因。虽然传统的治疗方法能够有效地去除原发肿瘤，但继发性肿瘤仍然难以治疗。有鉴于此，迫切需要新的治疗方法。在最有前途的方法中，越来越多的研究关注能够引发癌细胞局部细胞死亡并在整个机体中诱导免疫反应的免疫原性细胞死亡诱导剂。初步研究表明，免疫原性细胞死亡诱导化合物可能能够克服转移性和复发性肿瘤。本文系统地综述了金属配合物作为免疫原性细胞死亡诱导化合物的应用。
