Marks K E, Nelson C L, Lautenschlager E P
J Bone Joint Surg Am. 1976 Apr;58(3):358-64.
In vitro and in vivo experiments were performed to study the antibacterial and mechanical properties of Simplex and Palacos acrylic bone cements utilized for the production of acrylic cement-antibiotic composites. Acrylic cement without antibiotic had no bacteriostatic effect on Staphylococcus aureus, Escherichia coli, and Pseudomonas. Oxacillin, cefazolin, and gentamicin are stable in acrylic cement and are released in a microbiologically active form. The three antibiotics diffused from the Palacos in larger amounts daily and for a significantly longer time than from the Simplex. Mechanical tests demonstrated that admixture of antibiotics and acrylic cement had no influence on the compressive and diametral tension strengths of the cement. Bacteriostatic concentrations of oxacillin in wound hematomas were measured for fourteen days after implantation of an oxacillin-Simplex composite in dogs. High bactericidal concentrations of the antibiotic were measured in the surrounding bone for twenty-one days after implantation.
进行了体外和体内实验，以研究用于生产丙烯酸骨水泥-抗生素复合材料的Simplex和Palacos丙烯酸骨水泥的抗菌性能和力学性能。不含抗生素的丙烯酸骨水泥对金黄色葡萄球菌、大肠杆菌和假单胞菌没有抑菌作用。苯唑西林、头孢唑林和庆大霉素在丙烯酸骨水泥中稳定，并以微生物活性形式释放。这三种抗生素从Palacos中每日扩散的量更大，且扩散时间明显长于从Simplex中扩散的时间。力学测试表明，抗生素与丙烯酸骨水泥的混合对骨水泥的抗压强度和径向拉伸强度没有影响。在狗体内植入苯唑西林-Simplex复合材料后14天，测量伤口血肿中苯唑西林的抑菌浓度。植入后21天，在周围骨中测得该抗生素的高杀菌浓度。
