Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Liverpool John Moores University, Liverpool, UK.
Sci Rep. 2023 Feb 17;13(1):2835. doi: 10.1038/s41598-023-30050-y.
The amniotic membrane (AM) has special properties, making it ideal for clinical applications in various surgical fields like ophthalmology. It is used more frequently to cover conjunctival and corneal defects. In our retrospective study we have been combined 68 patients with epibulbar conjunctival tumors they have been surgically treated in the period of 2011-2021. Seven (10.3%) patients have been treated with AM application after surgical removal of the tumor. 54 (79%) cases were malignant, and 14 (21%) were benign. In the analyzed dataset the males had just slightly higher chance of malignancy than females, 80% versus 78.3%. For the significancy calculation the Fisher exact test was used and the result proved no significancy (p = 0.99). Six patients with AM application were malignant. The observed difference in the number of quadrants of the bulbar conjunctiva infiltrated versus significant malignancy with p = 0.050 calculated by Fisher Exact test and with p = 0.023 calculated by Likelihood-ratio test. The results of our study indicate that AM grafts are an effective alternative to cover defects after removal of epibulbar lesions due to their anti-inflammatory properties because the conjunctiva must be preserved, and especially the most important application is in malignant epibulbar conjunctival tumors.
羊膜（AM）具有特殊的特性，使其成为眼科等各种外科领域临床应用的理想选择。它更常用于覆盖结膜和角膜缺损。在我们的回顾性研究中，我们将 68 例眼外肿块患者进行了联合治疗，这些患者在 2011 年至 2021 年期间接受了手术治疗。在肿瘤切除后，有 7 例（10.3%）患者应用 AM。54 例（79%）为恶性，14 例（21%）为良性。在分析的数据集中，男性的恶性肿瘤发病几率略高于女性，分别为 80%和 78.3%。为了进行显著性计算，我们使用了 Fisher 确切检验，结果证明没有显著性差异（p=0.99）。在应用 AM 的 6 例患者中，有 6 例为恶性。通过 Fisher 确切检验计算，观察到在球结膜浸润的象限数与显著恶性肿瘤之间存在差异（p=0.050），通过似然比检验计算，结果为（p=0.023）。我们的研究结果表明，由于 AM 移植物具有抗炎特性，因此在切除眼外病变后覆盖缺损是一种有效的替代方法，因为必须保留结膜，特别是最重要的应用是在恶性眼外结膜肿瘤中。
