与分级力运动任务相关的 EEG 频谱功率随年龄的变化。
Aging-induced alterations in EEG spectral power associated with graded force motor tasks.
机构信息
Center for Mobility and Rehabilitation Engineering Research, Kessler Foundation, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA.
Department of Biomedical Engineering, Acıbadem Mehmet Ali Aydınlar University, Istanbul, Türkiye.
出版信息
Exp Brain Res. 2023 Mar;241(3):905-915. doi: 10.1007/s00221-023-06572-2. Epub 2023 Feb 20.
BACKGROUND
It has been demonstrated that in young and healthy individuals, there is a strong association between the amplitude of EEG-derived motor activity-related cortical potential or EEG spectral power (ESP) and voluntary muscle force. This association suggests that the motor-related ESP may serve as an index of central nervous system function in controlling voluntary muscle activation Therefore, it may potentially be used as an objective marker to track changes in functional neuroplasticity due to neurological disorders, aging, and following rehabilitation therapies. To this end, the relationship between the band-specific ESP-combined spectral power of EEG oscillatory and aperiodic (noise) components-and voluntary elbow flexion (EF) force has been analyzed in elder and young individuals.
METHODS
20 young (22.6 ± 0.87 year) and 28 elderly (74.79 ± 1.37 year) participants performed EF contractions at 20%, 50%, and 80% of maximum voluntary contraction (MVC) while high-density EEG signals were recorded. Both the absolute and relative ESPs were computed for the EEG frequency bands of interest.
RESULTS
The MVC force generated by the elderly was foreseeably lower than that of the young participants. Compared to young, the elderly cohort's (1) total ESP was significantly lower for the high (80% MVC) force task; (2) relative ESP in beta band was significantly elevated for the low and moderate (20% MVC and 50% MVC) force tasks; (3) absolute ESP failed to have a positive trend with force for EEG frequency bands of interest; and (4) beta-band relative ESP did not exhibit a significant decrease with increasing force levels.
CONCLUSIONS
As opposed to young subjects, the beta-band relative ESP in elderly did not significantly decrease with increasing EF force values. This observation suggests the use of beta-band relative ESP as a potential biomarker for age-related motor control degeneration.
背景
在年轻健康的个体中，脑电图衍生运动相关皮质电位或脑电图频谱功率（ESP）幅度与自愿肌肉力量之间存在很强的关联。这种关联表明，运动相关的 ESP 可能作为中枢神经系统控制自愿肌肉激活功能的指标。因此，它可能潜在地被用作跟踪由于神经障碍、衰老和康复治疗而导致的功能神经可塑性变化的客观标记。为此，分析了老年和年轻个体中脑电图振荡和非周期性（噪声）成分的特定频段 ESP-组合频谱功率与肘部自愿弯曲（EF）力量之间的关系。
方法
20 名年轻（22.6±0.87 岁）和 28 名老年人（74.79±1.37 岁）参与者在最大自愿收缩（MVC）的 20%、50%和 80%下进行 EF 收缩，同时记录高密度脑电图信号。计算了感兴趣的脑电图频段的绝对和相对 ESP。
结果
老年人产生的 MVC 力可预见低于年轻参与者。与年轻人相比，老年人队列的（1）高（80% MVC）力任务的总 ESP 明显较低；（2）低和中等（20% MVC 和 50% MVC）力任务的β波段相对 ESP 显著升高；（3）对于感兴趣的 EEG 频段，绝对 ESP 没有与力呈正相关趋势；（4）β波段相对 ESP 没有随着力水平的增加而显著降低。
结论
与年轻受试者不同，老年人的β波段相对 ESP 并没有随着 EF 力值的增加而显著降低。这一观察结果表明，β 波段相对 ESP 可作为与年龄相关的运动控制退化的潜在生物标志物。
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