• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

老年人结核病:来自西太平洋地区人口迅速老龄化的四个国家的案例研究。

Tuberculosis in older adults: case studies from four countries with rapidly ageing populations in the western pacific region.

机构信息

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.

出版信息

BMC Public Health. 2023 Feb 21;23(1):370. doi: 10.1186/s12889-023-15197-7.

DOI:10.1186/s12889-023-15197-7
PMID:36810018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9942033/
Abstract

BACKGROUND

The Western Pacific Region has one of the fastest-growing populations of older adults (≥ 65 years) globally, among whom tuberculosis (TB) poses a particular concern. This study reports country case studies from China, Japan, the Republic of Korea, and Singapore reflecting on their experiences in managing TB among older adults.

FINDINGS

Across all four countries, TB case notification and incidence rates were highest among older adults, but clinical and public health guidance focused on this population was limited. Individual country reports illustrated a range of practices and challenges. Passive case finding remains the norm, with limited active case finding (ACF) programs implemented in China, Japan, and the Republic of Korea. Different approaches have been trialled to assist older adults in securing an early diagnosis, as well as adhering to their TB treatment. All countries emphasised the need for person-centred approaches that include the creative application of new technology and tailored incentive programs, as well as reconceptualisation of how we provide treatment support. The use of traditional medicines was found to be culturally entrenched among older adults, with a need for careful consideration of their complementary use. TB infection testing and the provision of TB preventive treatment (TPT) were underutilised with highly variable practice.

CONCLUSION

Older adults require specific consideration in TB response policies, given the burgeoning aging population and their high TB risk. Policymakers, TB programs and funders must invest in and develop locally contextualised practice guidelines to inform evidence-based TB prevention and care practices for older adults.

摘要

背景

西太平洋区域是全球老年人口(≥65 岁)增长最快的区域之一,而结核病(TB)对该人群构成了特殊的挑战。本研究报告了来自中国、日本、韩国和新加坡的国家案例研究,反映了这些国家在管理老年结核病患者方面的经验。

发现

在这四个国家中,TB 的病例报告和发病率在老年人中最高,但针对这一人群的临床和公共卫生指导有限。个别国家的报告说明了一系列实践和挑战。被动病例发现仍然是常态,中国、日本和韩国仅实施了有限的主动病例发现(ACF)计划。已经尝试了不同的方法来帮助老年人尽早诊断和坚持他们的 TB 治疗。所有国家都强调需要以人为本的方法,包括创造性地应用新技术和定制激励计划,以及重新思考我们提供治疗支持的方式。发现传统药物在老年人中根深蒂固,需要仔细考虑其补充使用。TB 感染检测和提供 TB 预防性治疗(TPT)的使用率较低,实践情况差异很大。

结论

鉴于不断增长的老龄化人口和他们的高 TB 风险,老年人在 TB 应对政策中需要特别考虑。政策制定者、TB 项目和资助者必须投资并制定符合当地情况的实践指南,为老年人提供基于证据的 TB 预防和护理实践。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0b/9942279/bc85963ca614/12889_2023_15197_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0b/9942279/4282c8e9a4f5/12889_2023_15197_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0b/9942279/bc85963ca614/12889_2023_15197_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0b/9942279/4282c8e9a4f5/12889_2023_15197_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0b/9942279/bc85963ca614/12889_2023_15197_Fig2_HTML.jpg

相似文献

1
Tuberculosis in older adults: case studies from four countries with rapidly ageing populations in the western pacific region.老年人结核病:来自西太平洋地区人口迅速老龄化的四个国家的案例研究。
BMC Public Health. 2023 Feb 21;23(1):370. doi: 10.1186/s12889-023-15197-7.
2
Tuberculosis结核病
3
Tuberculosis in older adults: challenges and best practices in the Western Pacific Region.西太平洋地区老年人结核病:挑战与最佳实践
Lancet Reg Health West Pac. 2023 Apr 20;36:100770. doi: 10.1016/j.lanwpc.2023.100770. eCollection 2023 Jul.
4
[Expert consensus on tuberculosis preventive treatment for individuals at high risk of developing active diseases from latent tuberculosis infection in comprehensive medical facilities].综合医疗机构中潜伏结核感染后发生活动性疾病高危个体的结核病预防性治疗专家共识
Zhonghua Jie He He Hu Xi Za Zhi. 2024 Oct 12;47(10):933-945. doi: 10.3760/cma.j.cn112147-20240328-00173.
5
Incidence of Tuberculosis Among Immigrants in Korea Who Participated in a Latent Tuberculosis Infection Screening Program.韩国潜伏性结核感染筛查项目参与者中的移民结核病发病率。
J Korean Med Sci. 2024 Jul 22;39(28):e207. doi: 10.3346/jkms.2024.39.e207.
6
Fighting the tuberculosis epidemic in the Western Pacific region: current situation and challenges ahead.西太平洋地区抗击结核病流行:现状与未来挑战
Kekkaku. 2010 Jan;85(1):9-16.
7
Tuberculosis control in the Republic of Korea.韩国的结核病控制。
Epidemiol Health. 2018;40:e2018036. doi: 10.4178/epih.e2018036. Epub 2018 Aug 2.
8
Practices and attitudes towards tuberculosis and latent tuberculosis infection screening in people living with HIV/AIDS among HIV physicians in Japan.日本 HIV 医生对 HIV 感染者/艾滋病患者中结核病和潜伏性结核病感染筛查的实践和态度。
AIDS Res Ther. 2022 Dec 3;19(1):60. doi: 10.1186/s12981-022-00487-8.
9
Incidence and risk factors of active tuberculosis among older individuals with latent tuberculosis infection: a cohort study in two high-epidemic sites in eastern China.中国东部两个高流行地区潜伏性结核感染老年人中活动性结核的发生率和危险因素:一项队列研究。
Front Cell Infect Microbiol. 2024 Apr 29;14:1332211. doi: 10.3389/fcimb.2024.1332211. eCollection 2024.
10
Influenza and the risk of active tuberculosis occurrence among individuals with latent tuberculosis infection: A national cohort study in South Korea (2015-2020).流感与潜伏性结核感染个体中活动性结核病发生的风险:韩国的一项全国队列研究(2015-2020 年)。
J Microbiol Immunol Infect. 2024 Jun;57(3):437-445. doi: 10.1016/j.jmii.2024.04.003. Epub 2024 Apr 5.

引用本文的文献

1
Integrating Early Tuberculosis States Into Contact Management in Peru.将秘鲁早期结核病状态纳入接触者管理
JAMA Netw Open. 2025 Aug 1;8(8):e2525207. doi: 10.1001/jamanetworkopen.2025.25207.
2
The impact of population aging on tuberculosis prevention and control in Shanghai: a prediction based on age-period-cohort models.人口老龄化对上海结核病防控的影响:基于年龄-时期-队列模型的预测
Aging Clin Exp Res. 2025 May 28;37(1):175. doi: 10.1007/s40520-025-03070-z.
3
The Western Pacific Regional Framework to End TB: overview and critical reflection.

本文引用的文献

1
BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion.BLIMP1 和 NR4A3 转录因子相互调控抗肿瘤 CAR T 细胞干性和耗竭。
Sci Transl Med. 2022 Nov 9;14(670):eabn7336. doi: 10.1126/scitranslmed.abn7336.
2
Ending tuberculosis in China: health system challenges.终结中国结核病:卫生系统面临的挑战。
Lancet Public Health. 2021 Dec;6(12):e948-e953. doi: 10.1016/S2468-2667(21)00203-6.
3
Spatio-temporal variation in tuberculosis incidence and risk factors for the disease in a region of unbalanced socio-economic development.
《西太平洋区域终结结核病框架:概述与批判性反思》
IJTLD Open. 2025 Feb 1;2(2):64-72. doi: 10.5588/ijtldopen.24.0608. eCollection 2025 Feb.
4
Genomic characteristics of prospectively sequenced from respiratory and non-respiratory sources.来自呼吸道和非呼吸道样本的前瞻性测序的基因组特征。
iScience. 2024 Jun 20;27(7):110327. doi: 10.1016/j.isci.2024.110327. eCollection 2024 Jul 19.
5
Changing epidemic of tuberculosis amidst the COVID-19 pandemic in the Western Pacific Region: analysis of tuberculosis case notifications and treatment outcomes from 2015 to 2022.西太平洋地区新冠疫情期间结核病流行情况的变化:2015年至2022年结核病病例通报及治疗结果分析
Lancet Reg Health West Pac. 2024 Jun 5;47:101104. doi: 10.1016/j.lanwpc.2024.101104. eCollection 2024 Jun.
6
Timing and predictors of death during treatment in patients with multidrug/rifampin-resistant tuberculosis in South Korea.韩国耐多药/利福平耐药结核病患者治疗期间死亡的时间和预测因素。
Korean J Intern Med. 2024 Jul;39(4):640-649. doi: 10.3904/kjim.2024.029. Epub 2024 Jun 24.
7
High all-cause mortality and increasing proportion of older adults with tuberculosis in Texas, 2008-2020.2008-2020 年德克萨斯州全因死亡率高,且结核病老年患者比例增加。
Epidemiol Infect. 2024 May 13;152:e82. doi: 10.1017/S0950268824000669.
8
Risk factors for tuberculosis-related death among adults with drug-sensitive pulmonary tuberculosis in Selangor, Malaysia from 2013 to 2019: a retrospective cohort study using surveillance data.2013 年至 2019 年马来西亚雪兰莪州药物敏感性肺结核成人患者结核病相关死亡的危险因素:一项使用监测数据的回顾性队列研究。
BMJ Open. 2024 Feb 26;14(2):e080144. doi: 10.1136/bmjopen-2023-080144.
9
Tuberculosis in elderly Australians: a 10-year retrospective review.老年澳大利亚人群中的结核病:一项 10 年回顾性研究。
Western Pac Surveill Response J. 2024 Jan 5;15(1):1-10. doi: 10.5365/wpsar.2024.15.1.1040. eCollection 2024 Jan-Mar.
10
Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease.老年人的结核病和 COVID-19:导致疾病负担加重的因素。
Front Immunol. 2023 Sep 27;14:1250198. doi: 10.3389/fimmu.2023.1250198. eCollection 2023.
不平衡社会经济发展地区的结核病发病率及发病因素的时空变化。
BMC Public Health. 2021 Oct 9;21(1):1817. doi: 10.1186/s12889-021-11833-2.
4
Willingness to seek medical care for tuberculosis and associated factors among the elderly population in Shenzhen: a cross-sectional study.深圳老年人群结核病就医意愿及相关因素的横断面研究。
BMJ Open. 2021 Sep 21;11(9):e051291. doi: 10.1136/bmjopen-2021-051291.
5
Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study.评估 COVID-19 大流行对结核病服务的影响:一项全球研究。
Eur Respir J. 2021 Nov 11;58(5). doi: 10.1183/13993003.01786-2021. Print 2021 Nov.
6
TB in older people in Asia: why it is important.亚洲老年人中的结核病:为何重要。
Int J Tuberc Lung Dis. 2021 Jul 1;25(7):521-524. doi: 10.5588/ijtld.21.0191.
7
Analysis of the current status and associated factors of tuberculosis knowledge, attitudes, and practices among elderly people in Shenzhen: a cross-sectional study.深圳老年人结核病知识、态度和行为现状及相关因素分析:一项横断面研究
BMC Public Health. 2021 Jun 17;21(1):1163. doi: 10.1186/s12889-021-11240-7.
8
Temporal Trends in Notification and Mortality of Tuberculosis in China, 2004-2019: A Joinpoint and Age-Period-Cohort Analysis.2004 - 2019年中国结核病报告及死亡率的时间趋势:连接点与年龄 - 时期 - 队列分析
Int J Environ Res Public Health. 2021 May 24;18(11):5607. doi: 10.3390/ijerph18115607.
9
Status and Determinants of Treatment Outcomes Among New Tuberculosis Patients in South Korea: A Retrospective Cohort Study.韩国新结核病患者的治疗结局现状及其决定因素:一项回顾性队列研究。
Asia Pac J Public Health. 2021 Nov;33(8):907-913. doi: 10.1177/10105395211000529. Epub 2021 Apr 2.
10
Adherence and Associated Factors of Treatment Regimen in Drug-Susceptible Tuberculosis Patients.药物敏感型肺结核患者治疗方案的依从性及相关因素
Front Pharmacol. 2021 Mar 15;12:625078. doi: 10.3389/fphar.2021.625078. eCollection 2021.