Zhang Xiaomei, Lam Connie, Sim Eby, Martinez Elena, Crighton Taryn, Marais Ben J, Sintchenko Vitali
Centre for Research Excellence in Tuberculosis (TB-CRE), Centenary Institute, Sydney, NSW, Australia.
Sydney Infectious Diseases Institute (Sydney ID), The University of Sydney, Sydney, NSW, Australia.
iScience. 2024 Jun 20;27(7):110327. doi: 10.1016/j.isci.2024.110327. eCollection 2024 Jul 19.
Understanding the differences between strains isolated from respiratory and non-respiratory sources may inform clinical care and control strategies. We examined demographic and genomic characteristics of all culture-confirmed cultures isolated from respiratory and non-respiratory sources in New South Wales, Australia, from January 2017 to December 2021, using logistic regression models. strains from 1,831 patients were sequenced; 64.7% were from respiratory, 32.1% from non-respiratory, and 2.2% from both sources. Female patients had more frequent isolation from a non-respiratory source ( = 0.03), and older adults (≧65 years) from a respiratory source ( < 0.0001). Lineage 2 strains were relatively over-represented among respiratory isolates ( = 0.01). Among 39 cases with sequenced isolates from both sources, 43.6% had 1-10 single nucleotide polymorphism differences. The finding that older adults were more likely to have isolated from respiratory sources has relevance for TB control given the expected rise of TB among older adults.
了解从呼吸道和非呼吸道来源分离出的菌株之间的差异，可能会为临床护理和控制策略提供依据。我们使用逻辑回归模型，研究了2017年1月至2021年12月在澳大利亚新南威尔士州从呼吸道和非呼吸道来源分离出的所有培养确诊菌株的人口统计学和基因组特征。对1831名患者的菌株进行了测序；64.7%来自呼吸道，32.1%来自非呼吸道，2.2%来自这两个来源。女性患者从非呼吸道来源分离出菌株的频率更高（P = 0.03），而老年人（≧65岁）从呼吸道来源分离出菌株的频率更高（P < 0.0001）。谱系2菌株在呼吸道分离株中相对占比过高（P = 0.01）。在39例从两个来源均有测序分离株的病例中，43.6%有1-10个单核苷酸多态性差异。鉴于老年人中结核病预计会增加，老年人更有可能从呼吸道来源分离出菌株这一发现与结核病控制有关。
