Department of Dental Hygiene, Silla University, 140 Baegyang-daero 700beon-gil, Sasang-gu, Busan, 46958, Republic of Korea.
Department of Dental Hygiene, College of Health Sciences, Kangwon National University, 346 Hwangjo-Gil, Dogye-Up, Samcheok-Si, Gangwon-Do, 25945, Republic of Korea.
BMC Oral Health. 2023 Feb 21;23(1):116. doi: 10.1186/s12903-023-02816-3.
This study aimed to evaluate the antiplaque and antibacterial effects of a mouthwash containing Lespedeza cuneata (LC) extract through clinical periodontal disease (PD) indicators and changes in PD-causing bacteria.
A total of 63 subjects participated in this double-blind clinical trial. Subjects were divided into two groups: 32 participants gargled with LC extract, and 31 used saline. Scaling was performed 1 week before the experiment to secure the homogeneity of the subjects' oral conditions. After gargling with 15 ml of each solution for 1 min, participants spit out the solution to remove any residual mouthwash solution. Then, PD-related bacteria were measured via the O'Leary index, plaque index (PI), and gingival index (GI). The clinical data were collected three times: before gargling, immediately after gargling, and 5 d after gargling.
After 5 d, the O'Leary index, PI, and GI scores were significantly reduced in the LC extract gargle group (p < 0.05). PD-inducing Gram-positive and -negative bacteria were also reduced, confirming the LC extract's effect on periodontal health improvement and disease prevention.
Mouthwash containing LC extract, a new alternative natural substance that is safe and effective, may be used to treat PD because of its ability to inhibit and prevent PD.
本研究旨在通过临床牙周病（PD）指标和 PD 相关细菌的变化，评估一种含有胡枝子（LC）提取物的漱口水的抗菌斑和抗菌效果。
共有 63 名受试者参与了这项双盲临床试验。受试者分为两组：32 名受试者使用 LC 提取物漱口，31 名使用生理盐水。在实验前 1 周进行洁治术，以确保受试者口腔状况的同质性。用 15ml 每种溶液漱口 1 分钟后，受试者吐出溶液以去除任何残留的漱口水溶液。然后，通过 O'Leary 指数、菌斑指数（PI）和牙龈指数（GI）测量与 PD 相关的细菌。临床数据采集了三次：漱口前、漱口后立即和漱口后 5 天。
5 天后，LC 提取物漱口组的 O'Leary 指数、PI 和 GI 评分明显降低（p<0.05）。诱导牙周病的革兰氏阳性和阴性菌也减少了，证实了 LC 提取物对改善牙周健康和预防疾病的作用。
含 LC 提取物的漱口水可能是一种安全有效的新型天然替代物，可用于治疗 PD，因为它具有抑制和预防 PD 的能力。
