Department of Dental Hygiene, Silla University, Busan, South Korea.
Department of Dental Hygiene, College of Health Sciences, Kangwon National University, 346 Hwangjo-gil, Dogye-up, Samcheok-si, Gangwon-do, 25945, South Korea.
Sci Rep. 2022 Dec 1;12(1):20761. doi: 10.1038/s41598-022-25162-w.
This study aims to evaluate the anti-caries effect of a mouthwash containing Lespedeza cuneata extract by confirming its effect on acid-producing capacity and bacteria causing dental caries in the oral cavity. For the same oral environments of 95 subjects who agreed to participate in this study, scaling was performed one week before the experiment. The final number of subjects included in the analysis was 82, excluding those who dropped out during the study period. A randomized placebo-controlled trial was conducted by dividing the subjects into the Lespedeza cuneata extract gargle group (n = 42) and the saline gargle group (n = 40). Participants in each group gargled once every day before going to bed for 5 days, and data were collected by measuring 3 times: before gargling (Baseline), immediately after gargling (Treatment), and 5 days after gargling (After 5 Days). Two trained dental hygienists confirmed the dental caries activity through the Cariview test under the guidance of a dentist. Microbiological analysis was performed to evaluate the changes in bacteria causing dental caries. By confirming the anti-caries effect in the oral environment according to the application of Lespedeza cuneata extract gargle, dental caries activity was found to be significantly lower from Treatment to After 5 Days (p < 0.05). Dental caries-causing bacteria in the upper and lower jaws were also significantly reduced (p < 0.05). These results confirm that Lespedeza cuneata extract is a natural substance with an anti-caries effect. Gargling with a mouthwash containing Lespedeza cuneata extract is useful in preventing dental caries and inhibiting its progression. The same mouthwash can also be used as an effective formulation for maintaining and promoting oral health.
本研究旨在通过确认金雀花提取物对口内产酸能力和致龋菌的作用，评估其抗龋效果。对于 95 名同意参与本研究的受试者相同的口腔环境，在实验前一周进行了洁治。在研究期间脱落的受试者除外，最终纳入分析的受试者为 82 名。通过将受试者分为金雀花提取物漱口组（n = 42）和盐水漱口组（n = 40），进行了一项随机安慰剂对照试验。每组受试者每天睡前漱口一次，共 5 天，并在 3 次测量时收集数据：漱口前（基线）、漱口后立即（治疗）和漱口后 5 天（治疗后 5 天）。两名经过培训的口腔保健师在牙医的指导下通过 Cariview 测试确认龋齿活动度。进行微生物分析以评估致龋菌的变化。通过确认金雀花提取物漱口对口腔环境的抗龋效果，发现从治疗到治疗后 5 天（p < 0.05），龋齿活动度显著降低。上下颌的致龋菌也明显减少（p < 0.05）。这些结果证实金雀花提取物是一种具有抗龋效果的天然物质。使用含有金雀花提取物的漱口水漱口有助于预防龋齿及其进展。同样的漱口水也可作为维持和促进口腔健康的有效配方。
