Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China.
Colloids Surf B Biointerfaces. 2022 Jul;215:112491. doi: 10.1016/j.colsurfb.2022.112491. Epub 2022 Apr 6.
Porous tantalum-based biomaterial is a novel tissue engineering material widely used in repairing bone defects due to its corrosion resistance, low elastic modulus, high friction coefficient, and excellent biocompatibility. Bone marrow-derived mesenchymal stem cells (BMSCs), a type of pluripotent stem cell, can travel from their original ecological niche to bone injury sites, where they differentiate into osteoblasts and osteocytes. Multiple factors regulate the proliferation, migration, and differentiation of BMSCs. In recent years, the regulatory effects of porous tantalum on BMSCs have been widely studied. Hence, in this study, we reviewed the characteristics of porous tantalum-based biomaterials and the mechanism of action of their regulatory effects on BMSCs. Further, we discuss the feasibility of seeding BMSCs in porous tantalum-based biomaterials for use in tissue repair.
多孔钽基生物材料是一种新型组织工程材料，由于其耐腐蚀性、低弹性模量、高摩擦系数和良好的生物相容性，广泛应用于修复骨缺损。骨髓间充质干细胞（BMSCs）是一种多能干细胞，可以从其原始生态位迁移到骨损伤部位，分化为成骨细胞和骨细胞。多种因素调节 BMSCs 的增殖、迁移和分化。近年来，多孔钽对 BMSCs 的调节作用受到了广泛的研究。因此，在本研究中，我们综述了多孔钽基生物材料的特点及对 BMSCs 作用的调控机制，并探讨了在多孔钽基生物材料中种植 BMSCs 用于组织修复的可行性。
