Department of Radiotherapy, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, China.
PeerJ. 2023 Feb 16;11:e14930. doi: 10.7717/peerj.14930. eCollection 2023.
Aerobic glycolysis is a metabolic mode of tumor cells different from normal cells that plays an important role in tumor proliferation and distant metastasis. Radiotherapy has now become a routine and effective treatment for many malignancies, however, resistance to radiotherapy remains a major challenge in the treatment of malignant tumors. Recent studies have found that the abnormal activity of the aerobic glycolysis process in tumor cells is most likely involved in regulating chemoresistance and radiation therapy resistance in malignant tumors. However, research on the functions and mechanisms of aerobic glycolysis in the molecular mechanisms of resistance to radiotherapy in malignant tumors is still in its early stages. This review collects recent studies on the effects of aerobic glycolysis and radiation therapy resistance in malignant tumors, to further understand the progress in this area. This research may more effectively guide the clinical development of more powerful treatment plans for radiation therapy resistant subtypes of cancer patients, and take an important step to improve the disease control rate of radiation therapy resistant subtypes of cancer patients.
有氧糖酵解是一种不同于正常细胞的肿瘤细胞代谢模式，在肿瘤增殖和远处转移中发挥重要作用。放疗现已成为许多恶性肿瘤的常规有效治疗方法，但对放疗的抵抗仍然是恶性肿瘤治疗的主要挑战。最近的研究发现，肿瘤细胞中异常的有氧糖酵解过程的活动很可能参与调节恶性肿瘤的化疗耐药性和放疗抵抗性。然而，关于有氧糖酵解在恶性肿瘤放疗抵抗的分子机制中的功能和机制的研究仍处于早期阶段。这篇综述收集了最近关于有氧糖酵解和恶性肿瘤放疗抵抗的研究，以进一步了解这一领域的进展。这一研究可能更有效地指导针对放疗抵抗型癌症患者的更有力治疗方案的临床发展，并朝着提高放疗抵抗型癌症患者的疾病控制率迈出重要一步。
