Department of Dentistry, Keimyung University School of Medicine, Daegu, Korea.
Department of Preventive Medicine, Inje University College of Medicine, Busan, Korea.
Transplant Proc. 2023 Mar;55(2):350-353. doi: 10.1016/j.transproceed.2023.01.003. Epub 2023 Feb 20.
Various factors including diabetes and oxidative stress are associated with periodontal inflammation. End-stage renal disease causes various systemic abnormalities in patients, including cardiovascular disaese, metabolic abnormalities, and infection. Even after kidney transplantation (KT), these factors are known to be associated with inflammation. Our study, therefore, aimed to study risk factors associated with periodontitis in KT patients.
Patients who visited Dongsan Hospital, Daegu, Korea since 2018 and have undergone KT were selected. As of November 2021, 923 participants, with full data including hematologic factors were studied. Periodontitis was diagnosed based on residual bone level in panoramic views. Patients were studied by the presence of periodontitis.
From 923 KT patients, 30 were diagnosed with periodontal disease. Fasting glucose levels were higher in patients with periodontal disease, and total bilirubin levels were lower. When divided by fasting glucose levels, high glucose level showed increase of periodontal disease with odds ratio of 1.031 (95% confidence interval 1.004-1.060). After adjusting for confounders, the results were significant with odds ratio of 1.032 (95% CI 1.004-1.061).
Our study showed that KT patients, of whom uremic toxin clearance has been revolted, are yet at risk of periodontitis by other factors, such as high blood glucose levels.
多种因素，包括糖尿病和氧化应激，与牙周炎炎症有关。终末期肾病会导致患者出现各种全身异常，包括心血管疾病、代谢异常和感染。即使在肾移植 (KT) 后，这些因素也与炎症有关。因此，我们的研究旨在研究与 KT 患者牙周炎相关的危险因素。
选择自 2018 年以来在韩国大邱的 Dongsan 医院就诊并接受 KT 的患者。截至 2021 年 11 月，共研究了 923 名具有完整血液学因素数据的患者。根据全景视图中的残留骨水平诊断牙周炎。通过是否存在牙周炎来研究患者。
在 923 名 KT 患者中，有 30 名被诊断患有牙周病。患有牙周病的患者空腹血糖水平较高，总胆红素水平较低。按空腹血糖水平分组后，高血糖水平使牙周病的患病风险增加，比值比为 1.031（95%置信区间 1.004-1.060）。调整混杂因素后，比值比为 1.032（95%CI 1.004-1.061），结果仍具有统计学意义。
我们的研究表明，KT 患者虽然尿毒症毒素的清除得到了改善，但仍可能因其他因素（如高血糖水平）而面临牙周炎的风险。
