Jiao Yi, Wang Xing, Wang Qiong, Geng Qishun, Cao Xiaoxue, Zhang Mengxiao, Zhao Lu, Deng Tingting, Xu Yuan, Xiao Cheng
Beijing University of Chinese Medicine, China-Japan Friendship Clinical Medical College, Beijing, China.
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, China.
Front Pharmacol. 2023 Feb 6;14:1077796. doi: 10.3389/fphar.2023.1077796. eCollection 2023.
The immune system plays a crucial role in regulating osteoclast formation and function and has significance for the occurrence and development of immune-mediated bone diseases. Kidney-tonifying Chinese herbs, based on the theory of traditional Chinese medicine (TCM) to unify the kidney and strengthen the bone, have been widely used in the prevention and treatment of bone diseases. The common botanical drugs are tonifying kidney-yang and nourishing kidney-yin herbs, which are divided into two parts: one is the compound prescription of TCM, and the other is the single preparation of TCM and its active ingredients. These botanical drugs regulate osteoclastogenesis directly and indirectly by immune cells, however, we have limited information on the differences between the two botanical drugs in osteoimmunology. In this review, the mechanism by which kidney-tonifying Chinese herbs inhibiting osteoclastogenesis was investigated, emphasizing the immune response. The differences in the mechanism of action between tonifying kidney-yang herbs and nourishing kidney-yin herbs were analysed, and the therapeutic value for immune-mediated bone diseases was evaluated.
免疫系统在调节破骨细胞的形成和功能中起着关键作用，对免疫介导性骨病的发生和发展具有重要意义。补肾中药基于中医肾主骨理论，已广泛应用于骨病的防治。常见的植物药为补肾阳药和补肾阴药，分为两部分：一部分是中药复方，另一部分是中药单味制剂及其活性成分。这些植物药通过免疫细胞直接和间接调节破骨细胞生成，然而，关于这两种植物药在骨免疫学方面的差异，我们了解有限。在本综述中，研究了补肾中药抑制破骨细胞生成的机制，重点关注免疫反应。分析了补肾阳药和补肾阴药作用机制的差异，并评估了其对免疫介导性骨病的治疗价值。
