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螺环橘霉素醇A和B，来自于具有螺[色满-2,3'-异色满]骨架的橘霉素衍生物。

Spirocitrinols A and B, citrinin derivatives with a spiro[chromane-2,3'-isochromane] skeleton from .

作者信息

Tong Junjie, Zhang Yang, Xu Yang, Han Yangyang, Li Chuan, Zhuang Wenying, Che Yongsheng

机构信息

Tianjin University of Traditional Chinese Medicine Tianjin 300193 People's Republic of China.

NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100050 People's Republic of China

出版信息

RSC Adv. 2023 Feb 20;13(9):6124-6129. doi: 10.1039/d3ra00665d. eCollection 2023 Feb 14.

DOI:10.1039/d3ra00665d
PMID:36814878
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9940459/
Abstract

Spirocitrinols A (1) and B (2), two new citrinin-derived metabolites possessing a spiro[chromane-2,3'-isochromane] skeleton, were isolated from cultures of . Their structures were elucidated primarily by NMR experiments. The absolute configurations of 1 and 2 were assigned by electronic circular dichroism calculations. Compound 2 is the first naturally occurring trimeric citrinin derivative with a spiro[chromane-2,3'-isochromane] core. Compound 1 showed modest cytotoxicity against A549 human tumor cells.

摘要

螺环桔霉素醇A（1）和B（2）是两种新的由桔霉素衍生的代谢产物，具有螺[色满-2,3'-异色满]骨架，从……的培养物中分离得到。它们的结构主要通过核磁共振实验得以阐明。1和2的绝对构型通过电子圆二色性计算确定。化合物2是首个天然存在的具有螺[色满-2,3'-异色满]核心的三聚体桔霉素衍生物。化合物1对A549人肿瘤细胞显示出适度的细胞毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/66551fe5b1b1/d3ra00665d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/f2f62216e781/d3ra00665d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/a01a2cad3abe/d3ra00665d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/98948dd96a50/d3ra00665d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/8a5909e3e138/d3ra00665d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/942e64088ef0/d3ra00665d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/66551fe5b1b1/d3ra00665d-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/f2f62216e781/d3ra00665d-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/a01a2cad3abe/d3ra00665d-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/98948dd96a50/d3ra00665d-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/8a5909e3e138/d3ra00665d-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/942e64088ef0/d3ra00665d-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5ad/9940459/66551fe5b1b1/d3ra00665d-f6.jpg

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J Org Chem. 2022 Oct 7;87(19):13270-13279. doi: 10.1021/acs.joc.2c01856. Epub 2022 Sep 21.
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