从海绵共附生真菌SCSIO 41017中分离得到的聚酮化合物和甾体的细胞毒性
Cytotoxicity of polyketides and steroids isolated from the sponge-associated fungus SCSIO 41017.
作者信息
Salendra Limbadri, Lin Xiuping, Chen Weihao, Pang Xiaoyan, Luo Xiaowei, Long Jieyi, Liao Shengrong, Wang Junfeng, Zhou Xuefeng, Liu Yonghong, Yang Bin
机构信息
Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
University of Chinese Academy of Sciences, Beijing, China.
出版信息
Nat Prod Res. 2021 Mar;35(6):900-908. doi: 10.1080/14786419.2019.1610757. Epub 2019 May 31.
Two new polyketides, xerucitrinin A () and coniochaetone M (), and one new steroid, 16-methylpregna-17,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (), together with eleven known analogues were isolated from fungus SCSIO 41017 associated with the sponge sp. Their structures and absolute configurations were elucidated by NMR spectra, MS, CD, optical rotation, X-ray crystallography, and compared with literature data. Biological evaluation results revealed that exhibited significant cytotoxic activity against MCF-7 cell line with IC values of 1.3 M. Compound showed moderate activity against all cell lines with IC values of 13.5-18.0 M, and compounds and showed weak activity with MIC values of ranging from 125 g/mL to 250 g/mL respectively.[Formula: see text].
从与海绵sp.相关的真菌SCSIO 41017中分离出两种新的聚酮化合物，即干橘霉素A（）和附球菌酮M（），以及一种新的甾体化合物，16-甲基孕甾-17,19-二羟基-（9,11）-环氧-4-烯-3,18-二酮-20-乙酰氧基（），同时还分离出了十一种已知类似物。通过核磁共振光谱、质谱、圆二色光谱、旋光度、X射线晶体学对它们的结构和绝对构型进行了阐明，并与文献数据进行了比较。生物活性评价结果表明，对MCF-7细胞系表现出显著的细胞毒性活性，IC值为1.3μM。化合物对所有细胞系表现出中等活性，IC值为13.5 - 18.0μM，化合物和表现出较弱活性，MIC值分别为125μg/mL至250μg/mL。[分子式：见原文]
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