Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, 87036 Cosenza, Italy.
Health Center Srl, 87100 Cosenza, Italy.
Oxid Med Cell Longev. 2023 Feb 13;2023:1555942. doi: 10.1155/2023/1555942. eCollection 2023.
The traditional Mediterranean diet (MD) is characterized by a high phenolic-rich food intake, including in particular vegetables and fruits, but also legumes, whole grain cereals, nuts, and extra virgin olive oil. Evidence for beneficial effects of polyphenols in humans depends on the amount consumed and on their bioavailability. Here, we evaluated the association between the estimated polyphenol intake by fruits and vegetables food source and serum biochemical parameters in healthy adolescents, recruited into the DIMENU research project. Categorizing adolescents into three groups according to their estimated total polyphenol intake, we found that adolescents who declared high consumption of polyphenols had a higher adherence to the MD and had a better serum lipid profile than adolescents consuming low amounts of polyphenols. Moreover, using human HepG2 liver cells treated with oleic acid as an in vitro model for studying lipid accumulation, we showed that intracellular lipid accumulation is alleviated by serum from adolescents consuming a polyphenol-rich diet following MD recommendations. Our data underline the importance of promoting adherence to the typical MD foods as a superior strategy to prevent metabolic and chronic diseases and to ensure a better quality of life among adolescents.
传统的地中海饮食（MD）的特点是富含酚类化合物的食物摄入量高，包括特别是蔬菜和水果，但也包括豆类、全谷物谷物、坚果和特级初榨橄榄油。多酚对人类有益影响的证据取决于摄入量和生物利用度。在这里，我们评估了通过水果和蔬菜食物来源估计的多酚摄入量与健康青少年血清生化参数之间的关联，这些青少年被招募到 DIMENU 研究项目中。根据他们估计的总多酚摄入量，将青少年分为三组，我们发现，报告高多酚摄入量的青少年对 MD 的依从性更高，血清脂质谱也比摄入低量多酚的青少年更好。此外，我们使用油酸处理的人 HepG2 肝细胞作为研究脂质积累的体外模型，表明遵循 MD 建议的富含多酚的饮食的青少年的血清可以减轻细胞内脂质积累。我们的数据强调了促进对典型 MD 食物的依从性作为预防代谢和慢性疾病以及确保青少年更好生活质量的优越策略的重要性。
