Zhang Gang, Wang Xiaotong, Tong Mingyue, Chen Jian, Ji Qian
Department of Rehabilitation, The First Affiliated Hospital of Anhui Medical University, Anhui Public Health Clinical Center, Hefei, Anhui, 230000, People's Republic of China.
Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221000, People's Republic of China.
J Multidiscip Healthc. 2023 Jul 31;16:2167-2177. doi: 10.2147/JMDH.S420963. eCollection 2023.
In the United States (U.S.) general population, the association between standardized serum 25-hydroxyvitamin D (25(OH)D) concentration and risk of low muscle mass (LMM) remains unclear. Our research aimed to determine whether or not there was a relationship between serum 25(OH)D concentration and risk of LMM.
We analyzed the cross-sectional data of the US population that participated in the National Health and Nutrition Examination Survey between 2011 and 2014. The relationship between serum 25(OH)D concentration and LMM risk was evaluated using restricted cubic spline (RCS) with multivariate logistic regression model and subgroup analysis.
In all, we included 10,256 people in our analysis. The RCS plot demonstrated a U-shaped relationship between serum 25(OH)D concentration and risk of LMM ( for nonlinearity <0.05). At a Vitamin D concentration of 38.5 nmol/L, LMM risk was at its lowest. Based on analyses stratified by age, sex, hypertension, and diabetes mellitus (DM), serum 25(OH)D concentration and risk of LMM were U-curve correlated for those age 40 or older, male, with hypertension, or without DM. However, LMM risk was positively related to serum 25(OH)D concentration in those younger than age 40 or in women.
There is a U-shaped relationship between serum 25(OH)D concentration and the risk of LMM in the general U.S. population. Careful monitoring and appropriate Vitamin D supplementation might lessen the risk of LMM.
在美国普通人群中，标准化血清25-羟基维生素D（25(OH)D）浓度与低肌肉量（LMM）风险之间的关联仍不明确。我们的研究旨在确定血清25(OH)D浓度与LMM风险之间是否存在关系。
我们分析了2011年至2014年参加美国国家健康与营养检查调查的美国人群的横断面数据。使用受限立方样条（RCS）结合多变量逻辑回归模型和亚组分析评估血清25(OH)D浓度与LMM风险之间的关系。
我们总共纳入了10256人进行分析。RCS图显示血清25(OH)D浓度与LMM风险之间呈U形关系（非线性检验P<0.05）。当维生素D浓度为38.5 nmol/L时，LMM风险最低。根据年龄、性别、高血压和糖尿病（DM）分层分析，血清25(OH)D浓度与LMM风险在40岁及以上、男性、患有高血压或无DM的人群中呈U形曲线相关。然而，在40岁以下人群或女性中，LMM风险与血清25(OH)D浓度呈正相关。
在美国普通人群中，血清25(OH)D浓度与LMM风险之间存在U形关系。仔细监测和适当补充维生素D可能会降低LMM风险。
