Department of Urology, the Second Hospital of Shandong University, Jinan, Shandong, 250033, P.R. China.
Institute of Urology, Shandong University, Jinan, Shandong, 250033, P.R. China.
Sci Rep. 2017 Sep 5;7(1):10441. doi: 10.1038/s41598-017-09155-8.
To assess the correlation between penile hypersensitivity and premature ejaculation (PE), a total of 420 consecutive subjects attending our andrologic clinic for suspected PE were enrolled. The entire cohort was asked to complete the self-report intravaginal ejaculation latency time (IELT) by stopwatch. According to the IELT, the subjects were classified into 3 groups. Vibratory thresholds were recorded at the glans penis and penile shaft using a biothesiometer. We found that vibratory thresholds in the glans penis and penile shaft were significantly lower in both mild and severe PE group than in the control group (3.81 ± 0.57 and 3.54 ± 0.43 vs 4.73 ± 0.77 for glans penis p = 0.000; 3.64 ± 0.52 and 3.37 ± 0.50 vs 4.62 ± 0.69 for penile shaft p = 0.002). The vibratory threshold decreased as the disease aggravated. In the mild and severe PE groups, a significant positive correlation was detected between the mean values of IELT and the vibratory thresholds. Furthermore, in the receiver operating characteristics curve analysis, the area under the curve of the glans penis and penile shaft vibratory thresholds predicting severe PE were 0.852 and 0.893 respectively. Our study established a dose-dependent association between penile vibratory threshold and PE. Therefore, the vibratory threshold can serve as a potential marker for predicting the severity of PE.
为了评估阴茎敏感性与早泄（PE）之间的相关性，共招募了 420 名连续就诊于我们男科诊所疑似患有 PE 的患者。所有患者均通过秒表完成自我报告的阴道内射精潜伏期时间（IELT）。根据 IELT，将患者分为 3 组。使用生物感觉计记录阴茎龟头和阴茎干的振动阈值。我们发现，轻度和重度 PE 组的龟头和阴茎干振动阈值均明显低于对照组（龟头：3.81±0.57 对 4.73±0.77，p=0.000；阴茎干：3.64±0.52 对 4.62±0.69，p=0.002）。随着病情加重，振动阈值降低。在轻度和重度 PE 组中，IELT 的平均值与振动阈值之间存在显著正相关。此外，在受试者工作特征曲线分析中，预测重度 PE 的龟头和阴茎干振动阈值的曲线下面积分别为 0.852 和 0.893。本研究确立了阴茎振动阈值与 PE 之间存在剂量依赖性关联。因此，振动阈值可以作为预测 PE 严重程度的潜在标志物。
