Huang Junhui, Xu Fei, Yang Liping, Tuolihong Lina, Wang Xiaoyu, Du Zibo, Zhang Yiqi, Yin Xuanlin, Li Yingjun, Lu Kangrong, Wang Wanshan
Southern Medical University, Guangzhou, China.
Department of Psychiatry of School of Public Health, Southern Medical University, Guangzhou, China.
Front Mol Neurosci. 2023 Feb 1;16:1052288. doi: 10.3389/fnmol.2023.1052288. eCollection 2023.
The neurobiological mechanism of post-traumatic stress disorder (PTSD) is poorly understood. The inhibition of GABA neurons, especially in the amygdala, is crucial for the precise regulation of the consolidation, expression, and extinction of fear conditioning. The GABAergic system is involved in the pathophysiological process of PTSD, with several studies demonstrating that the function of the GABAergic system decreases in PTSD patients. This paper reviews the preclinical and clinical studies, neuroimaging techniques, and pharmacological studies of the GABAergic system in PTSD and summarizes the role of the GABAergic system in PTSD. Understanding the role of the GABAergic system in PTSD and searching for new drug targets will be helpful in the treatment of PTSD.
创伤后应激障碍（PTSD）的神经生物学机制尚未得到充分理解。抑制GABA能神经元，尤其是杏仁核中的GABA能神经元，对于精确调节恐惧条件反射的巩固、表达和消退至关重要。GABA能系统参与了PTSD的病理生理过程，多项研究表明PTSD患者的GABA能系统功能下降。本文综述了PTSD中GABA能系统的临床前和临床研究、神经影像学技术以及药理学研究，并总结了GABA能系统在PTSD中的作用。了解GABA能系统在PTSD中的作用并寻找新的药物靶点将有助于PTSD的治疗。
