University of Health Sciences, Koşuyolu High Specialization Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey.
University of Health Sciences, Bakırköy Dr. Sadi Konuk Research and Training Hospital, Department of Infectious Diseases, Istanbul, Turkey.
Acta Clin Croat. 2022 Aug;61(2):303-310. doi: 10.20471/acc.2022.61.02.17.
Pentraxin 3 (PTX3), a long pentraxin, is not only released from dendritic cells and neutrophils but also from epithelial and endothelial cells such as alveolar epithelium. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) initially activates the innate immune system, causing a complex immune response. Clinical and experimental studies suggest that PTX3, a locally and systemically secreted marker, can be used as a predictor of the severity and mortality in respiratory infections. In the current study, serum PTX3 levels in patients hospitalized with COVID-19 were found to be significantly increased at admission and showed significant association with the disease severity.
五聚素 3（PTX3）是一种长型五聚素，不仅可从树突状细胞和中性粒细胞中释放，也可从肺泡上皮等上皮细胞和内皮细胞中释放。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）最初激活先天免疫系统，引起复杂的免疫反应。临床和实验研究表明，局部和全身分泌的标志物 PTX3 可作为呼吸道感染严重程度和死亡率的预测指标。在本研究中，发现 COVID-19 住院患者入院时血清 PTX3 水平显著升高，并与疾病严重程度显著相关。
