Batson Trevor, Lee Junsoo, Kindler Joseph M, Pollock Norman K, Barbe Mary F, Modlesky Christopher M
Department of Kinesiology, University of Georgia, Athens, GA 30602, USA.
Department of Nutritional Sciences, University of Georgia, Athens, GA 30602, USA.
J Endocr Soc. 2023 Feb 2;7(4):bvad014. doi: 10.1210/jendso/bvad014. eCollection 2023 Feb 9.
Adults with cerebral palsy (CP) display a higher prevalence of cardiometabolic disease compared with the general population. Studies examining cardiometabolic disease risk in children with CP are limited.
The purpose of this study was to determine if children with CP exhibit higher cardiometabolic risk than typically developing children, and to examine its relationship with visceral adiposity and physical activity.
Thirty ambulatory children with CP and 30 age-, sex-, and race-matched typically developing control children were tested for blood lipids, glucose, and the homeostatic model assessment of insulin resistance (HOMA-IR). Visceral fat was assessed using dual-energy x-ray absorptiometry. Physical activity was assessed using accelerometer-based monitors.
Children with CP had higher total cholesterol, low-density lipoprotein cholesterol, and non-high-density lipoprotein cholesterol (non-HDL-C), glucose, prevalence of dyslipidemia, prevalence of prediabetes, and visceral fat mass index (VFMI) and lower physical activity than controls (all < .05). In the groups combined, non-HDL-C and glucose were positively related to VFMI ( = 0.337 and 0.313, respectively, < .05), and non-HDL-C and HOMA-IR were negatively related to physical activity ( = -0.411 and -0.368, respectively, < .05). HOMA-IR was positively related to VFMI in children with CP ( = 0.698, < .05), but not in controls. Glucose was not related to physical activity in children with CP, but it was negatively related in controls ( = -0.454, < .05).
Children with CP demonstrate early signs of cardiometabolic disease, which are more closely related to increased visceral adiposity than decreased physical activity.
与普通人群相比，成年脑瘫患者患心脏代谢疾病的比例更高。关于脑瘫患儿心脏代谢疾病风险的研究有限。
本研究旨在确定脑瘫患儿是否比正常发育儿童具有更高的心脏代谢风险，并探讨其与内脏脂肪过多和身体活动的关系。
对30名能独立行走的脑瘫患儿和30名年龄、性别及种族匹配的正常发育对照儿童进行血脂、血糖及胰岛素抵抗稳态模型评估（HOMA-IR）检测。采用双能X线吸收法评估内脏脂肪。使用基于加速度计的数据监测仪评估身体活动。
与对照组相比，脑瘫患儿的总胆固醇、低密度脂蛋白胆固醇、非高密度脂蛋白胆固醇（非HDL-C）、血糖、血脂异常患病率、糖尿病前期患病率、内脏脂肪质量指数（VFMI）更高，身体活动更少（均P<0.05）。在合并组中，非HDL-C和血糖与VFMI呈正相关（分别为r = 0.337和0.313，P<0.05），非HDL-C和HOMA-IR与身体活动呈负相关（分别为r = -0.411和-0.368，P<0.05）。在脑瘫患儿中，HOMA-IR与VFMI呈正相关（r = 0.698，P<0.05），但在对照组中无此相关性。在脑瘫患儿中，血糖与身体活动无相关性，但在对照组中呈负相关（r = -0.454，P<0.05）。
脑瘫患儿表现出心脏代谢疾病的早期迹象，这些迹象与内脏脂肪增多的关系比与身体活动减少的关系更为密切。
