Strakosas Xenofon, Biesmans Hanne, Abrahamsson Tobias, Hellman Karin, Ejneby Malin Silverå, Donahue Mary J, Ekström Peter, Ek Fredrik, Savvakis Marios, Hjort Martin, Bliman David, Linares Mathieu, Lindholm Caroline, Stavrinidou Eleni, Gerasimov Jennifer Y, Simon Daniel T, Olsson Roger, Berggren Magnus
Laboratory of Organic Electronics, Department of Science and Technology, Linköping University, 601 74 Norrköping, Sweden.
Chemical Biology and Therapeutics, Department of Experimental Medical Science, Lund University, SE-221 84 Lund, Sweden.
Science. 2023 Feb 24;379(6634):795-802. doi: 10.1126/science.adc9998. Epub 2023 Feb 23.
Interfacing electronics with neural tissue is crucial for understanding complex biological functions, but conventional bioelectronics consist of rigid electrodes fundamentally incompatible with living systems. The difference between static solid-state electronics and dynamic biological matter makes seamless integration of the two challenging. To address this incompatibility, we developed a method to dynamically create soft substrate-free conducting materials within the biological environment. We demonstrate in vivo electrode formation in zebrafish and leech models, using endogenous metabolites to trigger enzymatic polymerization of organic precursors within an injectable gel, thereby forming conducting polymer gels with long-range conductivity. This approach can be used to target specific biological substructures and is suitable for nerve stimulation, paving the way for fully integrated, in vivo-fabricated electronics within the nervous system.
将电子设备与神经组织连接对于理解复杂的生物功能至关重要，但传统生物电子设备由与生命系统根本不兼容的刚性电极组成。静态固态电子设备与动态生物物质之间的差异使得两者的无缝集成具有挑战性。为了解决这种不兼容性，我们开发了一种在生物环境中动态创建无软质基底导电材料的方法。我们在斑马鱼和水蛭模型中展示了体内电极的形成，利用内源性代谢物触发可注射凝胶中有机前体的酶促聚合，从而形成具有长程导电性的导电聚合物凝胶。这种方法可用于靶向特定的生物亚结构，适用于神经刺激，为神经系统内完全集成的体内制造电子设备铺平了道路。
