Liu Jincai, Li Xiang, Bai Huixin, Yang Xu, Mu Jun, Yan Ruonan, Wang Siwang
Northwest University Faculty of Life and Health Science, Northwest University, 229 Taibai Road, Xi'an, Shaanxi, 710069, China.
Northwest University Faculty of Life and Health Science, Northwest University, 229 Taibai Road, Xi'an, Shaanxi, 710069, China.
J Ethnopharmacol. 2023 May 23;308:116279. doi: 10.1016/j.jep.2023.116279. Epub 2023 Feb 22.
Moutan Cortex (MC), commonly known as "Mu dan pi", refers to the dried root bark of Paeonia x suffruticosa Andrews and is broadly used as a traditional herbal medication in China, Japan, and Korea. For thousands of years, it has been utilized to treat female genital, extravasated blood, cardiovascular, and stagnant blood disorders.
The purpose of this review article was to summarize information on the traditional uses, phytochemistry, pharmacology and pharmacokinetics of MC, as well as to outline the further research directions for the development of new drugs and the associations between traditional uses and pharmacological effects.
The information involved in the study was gathered from a variety of electronic resources, including PubMed, Web of Science, ScienceDirect, SciFinder, China Knowledge Resource Integrated Database, and Google Scholar. The date was from 1992 to 2022.
Approximately 163 chemical compounds have been extracted and identified from MC, including monoterpenes, monoterpene glycosides, triterpenes, phenolics, flavonoids, volatile oils, alkaloids, and others. In these categories, the monoterpene glycosides and phenols being the most common. A wide variety of pharmacological effects have been described for MC crude extracts and active molecules, such as antioxidant, anti-inflammatory, antibacterial and antiviral, antitumor, antidiabetic, organ protection, and neuroprotective activities, as well as treating cardiovascular diseases. Pharmacokinetics has been also used in the study of MC, including its crude extracts or chemical constituents, in order to explore the therapeutic mechanism, direct clinically appropriate application and provide new ideas for the exploitation of innovative medicines.
Modern pharmacological research has demonstrated that MC, as a significant therapeutic resource, has the ability to heal a wide range of diseases, particularly female genital and cardiovascular problems. These researches propose therapeutic ideas for the development of novel MC medicines. Furthermore, preclinical and clinical study have verified several observed pharmacological properties related with the traditional usages of MC.
牡丹皮（MC），俗称“牡丹皮”，是指牡丹的干燥根皮，在中国、日本和韩国被广泛用作传统草药。数千年来，它一直被用于治疗女性生殖系统疾病、瘀血、心血管疾病和血液瘀滞等病症。
这篇综述文章的目的是总结牡丹皮的传统用途、植物化学、药理学和药代动力学信息，并概述新药开发的进一步研究方向以及传统用途与药理作用之间的关联。
本研究涉及的信息来自多种电子资源，包括PubMed、科学网、ScienceDirect、SciFinder、中国知网和谷歌学术。数据时间范围为1992年至2022年。
已从牡丹皮中提取并鉴定出约163种化合物，包括单萜类、单萜糖苷、三萜类、酚类、黄酮类、挥发油、生物碱等。在这些类别中，单萜糖苷和酚类最为常见。牡丹皮粗提物和活性分子具有多种药理作用，如抗氧化、抗炎、抗菌和抗病毒、抗肿瘤、抗糖尿病、器官保护和神经保护活性，以及治疗心血管疾病。药代动力学也被用于牡丹皮的研究，包括其粗提物或化学成分，以探索治疗机制、指导临床合理应用并为创新药物开发提供新思路。
现代药理学研究表明，牡丹皮作为一种重要的治疗资源，有能力治愈多种疾病，特别是女性生殖系统疾病和心血管问题。这些研究为新型牡丹皮药物的开发提出了治疗思路。此外，临床前和临床研究已经证实了一些与牡丹皮传统用途相关的药理特性。
