典型饮食人群中膳食脂肪酸模式与非酒精性脂肪性肝病的关联：一项英国生物银行研究。
Associations between dietary fatty acid patterns and non-alcoholic fatty liver disease in typical dietary population: A UK biobank study.
作者信息
Tian Aowen, Sun Zewen, Zhang Miaoran, Li Jiuling, Pan Xingchen, Chen Peng
机构信息
Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun, Jilin, China.
Department of Pathology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.
出版信息
Front Nutr. 2023 Feb 7;10:1117626. doi: 10.3389/fnut.2023.1117626. eCollection 2023.
BACKGROUND AND AIMS
Dietary fatty acid composition is associated with non-alcoholic fatty liver disease (NAFLD). Few evidence had identified a clear role of dietary fatty acid composition of typical diet in NAFLD. We aimed to investigate the relationship between dietary patterns and NAFLD in populations with typical diets and to explore the effect of fatty acid composition in dietary patterns on NAFLD.
METHODS
Principal component analysis was used to identify 4 dietary patterns in UK Biobank participants. Logistic regression was used to estimate the association between dietary patterns and NAFLD. Mediation analysis was performed to evaluate the extent to which the relationship between dietary patterns and NAFLD was explained by dietary fatty acid combinations, as surrogated by serum fatty acids measured by nuclear magnetic resonance.
RESULTS
A dietary fatty acid pattern (DFP1) characterized by "PUFA enriched vegetarian" was negatively associated with NAFLD risk. Serum fatty acids were significantly associated with DFP1 and NAFLD. Mediation analysis showed SFA (27.8%, < 0.001), PUFA (25.1%, < 0.001), ω-6 PUFA (14.3%, < 0.001), LA (15.6%, < 0.001) and DHA (10%, < 0.001) had a significant indirect effect on the association between DFP1 and NAFLD. A dietary pattern characterized by "PUFA enriched carnivore" (DFP2) was not associated with NAFLD risk.
CONCLUSION
A "PUFA enriched vegetarian" dietary pattern with increased LA and DHA, may be beneficial for the treatment or prevention of NAFLD, while a "PUFA enriched carnivore" dietary pattern may not be harmful to NAFLD.
背景与目的
膳食脂肪酸组成与非酒精性脂肪性肝病（NAFLD）相关。很少有证据明确典型饮食的膳食脂肪酸组成在NAFLD中的作用。我们旨在研究典型饮食人群中膳食模式与NAFLD之间的关系，并探讨膳食模式中脂肪酸组成对NAFLD的影响。
方法
采用主成分分析确定英国生物银行参与者的4种膳食模式。采用逻辑回归估计膳食模式与NAFLD之间的关联。进行中介分析以评估膳食脂肪酸组合（通过核磁共振测量的血清脂肪酸替代）对膳食模式与NAFLD之间关系的解释程度。
结果
以“富含多不饱和脂肪酸的素食”为特征的膳食脂肪酸模式（DFP1）与NAFLD风险呈负相关。血清脂肪酸与DFP1和NAFLD显著相关。中介分析显示，饱和脂肪酸（SFA，27.8%，<0.001）、多不饱和脂肪酸（PUFA，25.1%，<0.001）、ω-6多不饱和脂肪酸（14.3%，<0.001）、亚油酸（LA，15.6%，<0.001）和二十二碳六烯酸（DHA，10%，<0.001）对DFP1与NAFLD之间的关联有显著间接影响。以“富含多不饱和脂肪酸的肉食者”为特征的膳食模式（DFP2）与NAFLD风险无关。
结论
富含LA和DHA的“富含多不饱和脂肪酸的素食”膳食模式可能有利于NAFLD的治疗或预防，而“富含多不饱和脂肪酸的肉食者”膳食模式可能对NAFLD无害。
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