Department of Clinical Studies, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Rhinebeck Equine LLP, Rhinebeck, New York, USA.
J Vet Intern Med. 2023 Mar;37(2):697-702. doi: 10.1111/jvim.16647. Epub 2023 Feb 24.
Anecdotal evidence suggests plasma transfusions increase serum amyloid A (SAA) concentrations in healthy neonatal foals making this marker of inflammation inappropriate for therapeutic decision making in such animals.
HYPOTHESIS/OBJECTIVES: Administration of hyperimmune fresh frozen plasma (FFP) increases SAA concentration in healthy foals and in foals with failure of transfer of passive immunity (FTPI).
Eighty-six healthy foals.
Prospective cohort study. Foals <24 hours of age receiving plasma transfusion for treatment of FTPI (serum immunoglobulin G [IgG] concentrations <8 g/L; n = 17) or as a preventative measure for Rhodococcus equi infection (IgG >8 g/L; n = 33) were enrolled. A healthy nontransfused group of foals (IgG >8 g/L; n = 21) also was included. Serum amyloid A concentration was determined before (t0h) and after (t24h) administration of FFP. Changes in blood SAA concentration were assessed using linear regression models.
No statistical differences were found in SAA concentration at t0h or t24h among the 3 groups (P > .05, for all comparisons). The variation in SAA concentration before (t0h) and after (t24h) plasma transfusion showed that administration of FFP was not associated with the changes in SAA concentration (P > .05). An association between SAA concentration at t0h and at 24 hours (P < .05) was identified, where foals with higher SAA concentration at t0h also had higher SAA concentration at t24h.
Administration of FFP to newborn foals was not associated with changes in SAA concentration.
有传闻证据表明，血浆输注会增加健康新生驹的血清淀粉样蛋白 A（SAA）浓度，使这种炎症标志物不适合此类动物的治疗决策。
假设/目的：给健康驹和未通过被动免疫转移（FTPI）的驹输注高免疫新鲜冷冻血浆（FFP）会增加 SAA 浓度。
86 匹健康驹。
前瞻性队列研究。<24 小时龄接受血浆输注治疗 FTPI（血清免疫球蛋白 G [IgG]浓度 <8 g/L；n = 17）或作为预防感染罗得西亚马鼻疽（Rhodococcus equi）的措施（IgG >8 g/L；n = 33）的驹。还纳入了一组未接受输血的健康驹（IgG >8 g/L；n = 21）。在输注 FFP 前（t0h）和后（t24h）测定血清 SAA 浓度。使用线性回归模型评估 SAA 浓度的变化。
在 3 组之间，t0h 或 t24h 时 SAA 浓度无统计学差异（所有比较，P >.05）。FFP 输注前后 SAA 浓度的变化表明，FFP 给药与 SAA 浓度的变化无关（P >.05）。在 t0h 和 24 小时（P <.05）时的 SAA 浓度之间存在关联，t0h 时 SAA 浓度较高的驹在 t24h 时的 SAA 浓度也较高。
给新生驹输注 FFP 与 SAA 浓度的变化无关。
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