Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences (NMBU), Ås, Norway.
Microbiologyopen. 2023 Feb;12(1):e1338. doi: 10.1002/mbo3.1338.
As bacteria proliferate, DNA replication, chromosome segregation, cell wall synthesis, and cytokinesis occur concomitantly and need to be tightly regulated and coordinated. Although these cell cycle processes have been studied for decades, several mechanisms remain elusive, specifically in coccus-shaped cells such as Staphylococcus aureus. In recent years, major progress has been made in our understanding of how staphylococci divide, including new, fundamental insights into the mechanisms of cell wall synthesis and division site selection. Furthermore, several novel proteins and mechanisms involved in the regulation of replication initiation or progression of the cell cycle have been identified and partially characterized. In this review, we will summarize our current understanding of the cell cycle processes in the spheroid model bacterium S. aureus, with a focus on recent advances in the understanding of how these processes are regulated.
随着细菌的增殖，DNA 复制、染色体分离、细胞壁合成和细胞分裂同时发生，需要进行严格的调节和协调。尽管这些细胞周期过程已经研究了几十年，但仍有一些机制尚未被揭示，特别是在球菌形细胞如金黄色葡萄球菌中。近年来，人们对葡萄球菌如何分裂有了更深入的了解，包括对细胞壁合成和分裂位点选择机制的新的基本认识。此外，还发现了几个参与调控复制起始或细胞周期进程的新蛋白和机制，并对其进行了部分表征。在这篇综述中，我们将总结我们目前对球形模式菌金黄色葡萄球菌细胞周期过程的理解，重点介绍对这些过程如何被调控的最新认识。
