Ramos-León Félix, Ramamurthi Kumaran S
Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.
Biochem Soc Trans. 2025 Apr 17;53(2):447-60. doi: 10.1042/BST20240956.
Many bacteria divide by binary fission, producing two identical daughter cells, which requires proper placement of the division machinery at mid-cell. Spherical bacteria (cocci) face unique challenges due to their lack of natural polarity. In this review, we compile current knowledge on how cocci regulate cell division, how they select the proper division plane, and ensure accurate Z-ring positioning at mid-cell. While Streptococcus pneumoniae and Staphylococcus aureus are the most well-studied models for cell division in cocci, we also cover other less-characterized cocci across different bacterial groups and discuss the conservation of known Z-ring positioning mechanisms in these understudied bacteria.
许多细菌通过二分裂进行繁殖，产生两个相同的子细胞，这需要将分裂机制正确地定位在细胞中部。球形细菌（球菌）由于缺乏天然极性而面临独特的挑战。在本综述中，我们汇总了关于球菌如何调节细胞分裂、如何选择合适的分裂平面以及如何确保Z环在细胞中部准确定位的现有知识。虽然肺炎链球菌和金黄色葡萄球菌是球菌细胞分裂研究最多的模型，但我们也涵盖了不同细菌类群中其他特征较少的球菌，并讨论了这些研究较少的细菌中已知Z环定位机制的保守性。
