Nie Shuyi
School of Biological Sciences, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA.
J Cardiovasc Dev Dis. 2023 Jan 29;10(2):51. doi: 10.3390/jcdd10020051.
A frog is a classical model organism used to uncover processes and regulations of early vertebrate development, including heart development. Recently, we showed that a frog also represents a useful model to study a rare human congenital heart disease, hypoplastic left heart syndrome. In this review, we first summarized the cellular events and molecular regulations of vertebrate heart development, and the benefit of using a frog model to study congenital heart diseases. Next, we described the challenges in elucidating the etiology of hypoplastic left heart syndrome and discussed how a frog model may contribute to our understanding of the molecular and cellular bases of the disease. We concluded that a frog model offers its unique advantage in uncovering the cellular mechanisms of hypoplastic left heart syndrome; however, combining multiple model organisms, including frogs, is needed to gain a comprehensive understanding of the disease.
青蛙是一种经典的模式生物，用于揭示早期脊椎动物发育的过程和调控机制，包括心脏发育。最近，我们发现青蛙也是研究一种罕见的人类先天性心脏病——左心发育不全综合征的有用模型。在这篇综述中，我们首先总结了脊椎动物心脏发育的细胞事件和分子调控机制，以及使用青蛙模型研究先天性心脏病的益处。接下来，我们描述了阐明左心发育不全综合征病因方面的挑战，并讨论了青蛙模型如何有助于我们理解该疾病的分子和细胞基础。我们得出结论，青蛙模型在揭示左心发育不全综合征的细胞机制方面具有独特优势；然而，需要结合包括青蛙在内的多种模式生物，才能全面了解该疾病。
