Bettiol Alessandra, Urban Maria Letizia, Emmi Giacomo, Galora Silvia, Argento Flavia Rita, Fini Eleonora, Borghi Serena, Bagni Giacomo, Mattioli Irene, Prisco Domenico, Fiorillo Claudia, Becatti Matteo
Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy.
Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, Firenze, Italy.
Front Mol Biosci. 2024 Jan 18;10:1325002. doi: 10.3389/fmolb.2023.1325002. eCollection 2023.
Thrombosis is a major cause of morbidity and mortality worldwide, with a complex and multifactorial pathogenesis. Recent studies have shown that SIRT1, a member of the sirtuin family of NAD + -dependent deacetylases, plays a crucial role in regulating thrombosis, modulating key pathways including endothelial activation, platelet aggregation, and coagulation. Furthermore, SIRT1 displays anti-inflammatory activity both , and in clinical studies, particularly via the reduction of oxidative stress. On these bases, several studies have investigated the therapeutic potential of targeting SIRT1 for the prevention of thrombosis. This review provides a comprehensive and critical overview of the main preclinical and clinical studies and of the current understanding of the role of SIRT1 in thrombosis.
血栓形成是全球发病和死亡的主要原因，其发病机制复杂且具有多因素性。最近的研究表明，SIRT1作为烟酰胺腺嘌呤二核苷酸（NAD+）依赖性脱乙酰酶的沉默调节蛋白家族成员，在调节血栓形成、调控包括内皮细胞激活、血小板聚集和凝血在内的关键途径中发挥着至关重要的作用。此外，SIRT1在临床前研究和临床研究中均表现出抗炎活性，特别是通过降低氧化应激来实现。基于这些，多项研究探讨了靶向SIRT1预防血栓形成的治疗潜力。本综述全面且批判性地概述了主要的临床前和临床研究，以及目前对SIRT1在血栓形成中作用的理解。
