Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain.
Biomedical Research Institute of Malaga (IBIMA), Endocrinology and Nutrition Department, Regional University Hospital of Malaga, Malaga, Spain.
Sci Rep. 2020 Feb 17;10(1):2765. doi: 10.1038/s41598-020-59643-7.
Our aim was to determine the incidence of type 2 diabetes mellitus in a nation-wide population based cohort from Spain (di@bet.es study). The target was the Spanish population. In total 5072 people older than 18 years,were randomly selected from all over Spain). Socio-demographic and clinical data, survey on habits (physical activity and food consumption) and weight, height, waist, hip and blood pressure were recorder. A fasting blood draw and an oral glucose tolerance test were performed. Determinations of serum glucose were made. In the follow-up the same variables were collected and HbA1c was determined. A total of 2408 subjects participated in the follow-up. In total, 154 people developed diabetes (6.4% cumulative incidence in 7.5 years of follow-up). The incidence of diabetes adjusted for the structure of age and sex of the Spanish population was 11.6 cases/1000 person-years (IC95% = 11.1-12.1). The incidence of known diabetes was 3.7 cases/1000 person-years (IC95% = 2.8-4.6). The main risk factors for developing diabetes were the presence of prediabetes in cross-sectional study, age, male sex, obesity, central obesity, increase in weight, and family history of diabetes. This work provides data about population-based incidence rates of diabetes and associated risk factors in a nation-wide cohort of Spanish population.
我们的目的是在西班牙的全国人群队列中确定 2 型糖尿病的发病率（di@bet.es 研究）。目标人群是西班牙人口。共有 5072 名年龄在 18 岁以上的人从西班牙各地随机抽取）。记录社会人口统计学和临床数据、习惯调查（体育活动和食物消费）以及体重、身高、腰围、臀围和血压。进行空腹采血和口服葡萄糖耐量试验。测定血清葡萄糖。在随访中收集了相同的变量，并测定了 HbA1c。共有 2408 名受试者参加了随访。共有 154 人患上了糖尿病（7.5 年随访期间的累积发病率为 6.4%）。根据西班牙人口的年龄和性别结构调整后的糖尿病发病率为 11.6 例/1000 人年（95%CI95%=11.1-12.1）。已知糖尿病的发病率为 3.7 例/1000 人年（95%CI95%=2.8-4.6）。发生糖尿病的主要危险因素是在横断面研究中存在前驱糖尿病、年龄、男性、肥胖、中心性肥胖、体重增加和糖尿病家族史。这项工作提供了关于西班牙全国人群队列中基于人群的糖尿病发病率和相关危险因素的数据。
