Silén Heidi, Salih Enass Y A, Mgbeahuruike Eunice Ego, Fyhrqvist Pia
Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, 00014 Helsinki, Finland.
Antibiotics (Basel). 2023 Jan 28;12(2):264. doi: 10.3390/antibiotics12020264.
Bacterial and fungal resistance to antibiotics is of growing global concern. Plants such as the African and species, which are used in traditional medicine for the treatment of infections, could be good sources for antimicrobial extracts, drug scaffolds, and/or antibiotic adjuvants. In African countries, plant species are often used in combinations as traditional remedies. It is suggested that the plant species enhance the effects of each other in these combination treatments. Thus, the multi-species-containing herbal medications could have a good antimicrobial potency. In addition, plant extracts and compounds are known to potentiate the effects of antibiotics. The objective of this review is to compile the information on the botany, ethnopharmacology, ethnobotany, and appearance in herbal markets of African species of the genera and . With this ethnobotanical information as a background, this review summarizes the information on the phytochemistry and antimicrobial potency of the extracts and their active compounds, as well as their combination effects with conventional antibiotics. The databases used for the literature search were Scopus, Elsevier, EBSCOhost, PubMed, Google Scholar, and SciFinder. In summary, a number of and species were reported to display significant in vitro antibacterial and antifungal efficacy. Tannins, terpenes, flavonoids, stilbenes, and alkaloids-some of them with good antimicrobial potential-are known from species of the genera and . Among the most potent antimicrobial compounds are arjunglucoside I (MIC 1.9 µg/mL) and imberbic acid (MIC 1.56 µg/mL), found in both genera and in some species, respectively. The in vitro antimicrobial properties of the extracts and compounds of many and species support their traditional medicinal uses.
细菌和真菌对抗生素的耐药性日益引起全球关注。非洲的一些植物物种，如[具体物种]，在传统医学中用于治疗感染，可能是抗菌提取物、药物支架和/或抗生素佐剂的良好来源。在非洲国家，植物物种经常被组合用作传统药物。据推测，这些植物物种在这些联合治疗中相互增强疗效。因此，含有多种植物的草药可能具有良好的抗菌效力。此外，已知植物提取物和化合物可增强抗生素的作用。本综述的目的是汇编关于[具体属]非洲物种的植物学、民族药理学、民族植物学以及在草药市场上的外观等信息。以这些民族植物学信息为背景，本综述总结了关于提取物及其活性化合物的植物化学和抗菌效力的信息，以及它们与传统抗生素的联合作用。用于文献检索的数据库有Scopus、Elsevier、EBSCOhost、PubMed、谷歌学术和SciFinder。总之，据报道许多[具体属]物种在体外显示出显著的抗菌和抗真菌功效。从[具体属]物种中已知有单宁、萜类、黄酮类、芪类和生物碱——其中一些具有良好的抗菌潜力。在最有效的抗菌化合物中，分别在两个属和一些[具体物种]中发现了阿江榄仁苷I（最低抑菌浓度为1.9微克/毫升）和imbric acid（最低抑菌浓度为1.56微克/毫升）。许多[具体属]物种的提取物和化合物的体外抗菌特性支持了它们的传统药用价值。
