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新型骨架黄烷生物碱的全合成。

Total Synthesis of Novel Skeleton Flavan-Alkaloids.

机构信息

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA.

The New Use Agriculture and Natural Plant Products Program, Department of Plant Biology, Rutgers University, 59 Dudley Road, New Brunswick, NJ 08901, USA.

出版信息

Molecules. 2020 Sep 30;25(19):4491. doi: 10.3390/molecules25194491.

DOI:10.3390/molecules25194491
PMID:33007965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7582810/
Abstract

The first total synthesis of novel skeleton natural compounds kinkeloids A and B, a group of newly discovered flavan alkaloids isolated from the African plant , are described in this study. The key and final step are achieved by Mannich reaction, through which the piperidine moiety couples to the flavan moiety. The identities of synthesized kinkeloids were further confirmed through a comparison with the ones in the plant leaves extract using LC/MS.

摘要

本文首次全合成了新型骨架天然化合物金壳素 A 和 B，它们是从非洲植物中分离出的一组新发现的黄烷生物碱。关键和最后一步是通过曼尼希反应实现的，其中哌啶部分与黄烷部分偶联。通过与植物叶片提取物中的化合物进行 LC/MS 比较，进一步证实了合成的金壳素的结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/0d0addb3b22e/molecules-25-04491-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/c9c5b1d2b9ab/molecules-25-04491-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/7d4319b5d38d/molecules-25-04491-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/28113ad327df/molecules-25-04491-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/0d0addb3b22e/molecules-25-04491-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/c9c5b1d2b9ab/molecules-25-04491-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/7d4319b5d38d/molecules-25-04491-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/28113ad327df/molecules-25-04491-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41fd/7582810/0d0addb3b22e/molecules-25-04491-sch003.jpg

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