College of Animal Sciences, Zhejiang University, Hangzhou 310000, China.
Hainan Institute, Zhejiang University, Sanya 572000, China.
Cells. 2023 Feb 14;12(4):613. doi: 10.3390/cells12040613.
The placenta plays a crucial role in mammalian fetal growth. The most important cell type in the placenta is the trophoblast cell. Many genes have been reported to play important functions in the differentiation of early placental trophoblast cells. Weighted gene co-expression network analysis (WGCNA) is a systematic biological method for describing the correlation patterns among genes across microarray samples. We used WGCNA to screen placental trophoblast development-related genes, and through experimental confirmation, we showed that, among these genes, ELAC2 may play an important regulatory role in the early development of mammalian placental formation. ELAC2 regulates early placental trophoblast differentiation by affecting cell migration and cell proliferation. In addition, ELAC2 may be involved in regulating cell migration processes in a manner that affects epithelial mesenchymal transition (EMT).
胎盘在哺乳动物胎儿生长中起着至关重要的作用。胎盘最重要的细胞类型是滋养层细胞。有许多基因已被报道在早期胎盘滋养层细胞的分化中发挥重要作用。加权基因共表达网络分析（WGCNA）是一种系统的生物方法，用于描述微阵列样本中基因之间的相关模式。我们使用 WGCNA 筛选胎盘滋养层发育相关基因，并通过实验验证，表明其中的 ELAC2 可能在哺乳动物胎盘形成的早期发育中发挥重要的调节作用。ELAC2 通过影响细胞迁移和细胞增殖来调节早期胎盘滋养层的分化。此外，ELAC2 可能通过影响上皮间质转化（EMT）来调节细胞迁移过程。
