Zachou Maria-Eleni, Kouloulias Vassilis, Chalkia Marina, Efstathopoulos Efstathios, Platoni Kalliopi
2nd Department of Radiology, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Cancers (Basel). 2024 Jan 17;16(2):0. doi: 10.3390/cancers16020393.
This article presents a comprehensive review of nanoparticle-assisted treatment approaches for soft tissue sarcoma (STS). STS, a heterogeneous group of mesenchymal-origin tumors with aggressive behavior and low overall survival rates, necessitates the exploration of innovative therapeutic interventions. In contrast to conventional treatments like surgery, radiotherapy (RT), hyperthermia (HT), and chemotherapy, nanomedicine offers promising advancements in STS management. This review focuses on recent research in nanoparticle applications, including their role in enhancing RT and HT efficacy through improved drug delivery systems, novel radiosensitizers, and imaging agents. Reviewing the current state of nanoparticle-assisted therapies, this paper sheds light on their potential to revolutionize soft tissue sarcoma treatment and improve patient therapy outcomes.
本文全面综述了纳米颗粒辅助治疗软组织肉瘤(STS)的方法。STS是一组起源于间充质的异质性肿瘤,具有侵袭性且总体生存率较低,因此需要探索创新的治疗干预措施。与手术、放疗(RT)、热疗(HT)和化疗等传统治疗方法不同,纳米医学在STS治疗方面提供了有前景的进展。本综述重点关注纳米颗粒应用的最新研究,包括它们通过改进药物递送系统、新型放射增敏剂和成像剂在提高RT和HT疗效方面的作用。通过回顾纳米颗粒辅助治疗的现状,本文揭示了它们在彻底改变软组织肉瘤治疗并改善患者治疗结果方面的潜力。