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癌症免疫疗法洞察:近期突破、机遇与挑战

Insights into Cancer Immunotherapies: Recent Breakthroughs, Opportunities, and Challenges.

作者信息

Pappas Evan G, Kershaw Michael H, Slaney Clare Y

机构信息

Cancer Immunology Program, Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia.

出版信息

Cancers (Basel). 2023 Feb 19;15(4):1322. doi: 10.3390/cancers15041322.

DOI:10.3390/cancers15041322
PMID:36831663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9954646/
Abstract

This Special Issue reminds us that, although incredible developments have occurred in the field of cancer immunotherapy, there is still plenty of room for improvement [...].

摘要

本期特刊提醒我们,尽管癌症免疫治疗领域已经取得了令人难以置信的进展,但仍有很大的改进空间[...]。

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本文引用的文献

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Enhancing Adoptive Cell Transfer with Combination BRAF-MEK and CDK4/6 Inhibitors in Melanoma.联合BRAF-MEK和CDK4/6抑制剂增强黑色素瘤的过继性细胞转移
Cancers (Basel). 2021 Dec 17;13(24):6342. doi: 10.3390/cancers13246342.
2
Nonreplicating Adenoviral Vectors: Improving Tropism and Delivery of Cancer Gene Therapy.非复制型腺病毒载体:改善癌症基因治疗的靶向性与递送
Cancers (Basel). 2021 Apr 14;13(8):1863. doi: 10.3390/cancers13081863.
3
Ropporin-1 and 1B Are Widely Expressed in Human Melanoma and Evoke Strong Humoral Immune Responses.Ropporin-1和1B在人类黑色素瘤中广泛表达并引发强烈的体液免疫反应。
Cancers (Basel). 2021 Apr 9;13(8):1805. doi: 10.3390/cancers13081805.
4
Immune Checkpoint Blockade in HER2-Positive Breast Cancer: What Role in Early Disease Setting?人表皮生长因子受体2阳性乳腺癌中的免疫检查点阻断:在早期疾病中的作用是什么?
Cancers (Basel). 2021 Apr 1;13(7):1655. doi: 10.3390/cancers13071655.
5
Myxoma Virus Expressing LIGHT (TNFSF14) Pre-Loaded into Adipose-Derived Mesenchymal Stem Cells Is Effective Treatment for Murine Pancreatic Adenocarcinoma.预先加载到脂肪来源间充质干细胞中的表达LIGHT(肿瘤坏死因子配体超家族成员14)的黏液瘤病毒是治疗小鼠胰腺腺癌的有效方法。
Cancers (Basel). 2021 Mar 19;13(6):1394. doi: 10.3390/cancers13061394.
6
TAM Receptor Inhibition-Implications for Cancer and the Immune System.TAM 受体抑制作用——对癌症和免疫系统的影响
Cancers (Basel). 2021 Mar 10;13(6):1195. doi: 10.3390/cancers13061195.
7
Metabolic and Mitochondrial Functioning in Chimeric Antigen Receptor (CAR)-T Cells.嵌合抗原受体(CAR)-T细胞中的代谢与线粒体功能
Cancers (Basel). 2021 Mar 11;13(6):1229. doi: 10.3390/cancers13061229.
8
Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model.在Jurkat T细胞模型中,将嵌合抗原受体(CAR)靶向至肽-主要组织相容性复合体(peptide-MHC complex)所揭示的信号传导与T细胞受体(TCR)不同。
Cancers (Basel). 2021 Feb 18;13(4):867. doi: 10.3390/cancers13040867.
9
Natural Killer Cells and Anti-Cancer Therapies: Reciprocal Effects on Immune Function and Therapeutic Response.自然杀伤细胞与抗癌疗法:对免疫功能和治疗反应的相互影响
Cancers (Basel). 2021 Feb 9;13(4):711. doi: 10.3390/cancers13040711.
10
Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy.利用肿瘤坏死因子α实现有效的癌症免疫治疗。
Cancers (Basel). 2021 Feb 2;13(3):564. doi: 10.3390/cancers13030564.