Xia Mengyao, Zhao Tingting, Wang Xiaolong, Li Yang, Li Yanling, Zheng Tingting, Li Jiaxin, Feng Yu, Wei Yongli, Sun Peng
Department of Pharmacology, School of Pharmacy, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China.
Center for Foreign Language Translation, College of Foreign Languages, Shandong University of Traditional Chinese Medicine, Ji'nan250355, China.
Iran J Pharm Res. 2021 Fall;20(4):137-151. doi: 10.22037/ijpr.2021.115705.15484.
Brain-derived neurotrophic factor () is a protein that performs a neurotrophic function. and its receptors are widely expressed in the nervous system and can promote the growth of neurons and the formation of neuronal synapses in the brain. Studies have shown that a lack of can lead to impairment of memory and cognitive functions, indicating that plays an important role in mental illness and neurodegenerative diseases. The combination of stem cells and -releasing nanomaterials holds great promise in regenerative medicine, especially in the treatment of neurological diseases. For example, Alzheimer's disease, depression, Parkinson's disease, spinal cord injury, etc. The combination of stem cell/pharmacologically active carrier and -nano/hydrogel provided a useful new type of local delivery tool for the treatment of the nervous system and other diseases. It can not only provide but also stem cells. These studies will provide a scientific basis for the development and application of in the future.
脑源性神经营养因子（）是一种具有神经营养功能的蛋白质。其及其受体在神经系统中广泛表达，可促进神经元的生长和大脑中神经元突触的形成。研究表明，缺乏会导致记忆和认知功能受损，这表明在精神疾病和神经退行性疾病中起重要作用。干细胞与释放的纳米材料的结合在再生医学中具有巨大潜力，尤其是在治疗神经疾病方面。例如，阿尔茨海默病、抑郁症、帕金森病、脊髓损伤等。干细胞/药理活性载体与纳米/水凝胶的结合为治疗神经系统疾病和其他疾病提供了一种新型的局部递送工具。它不仅可以提供，还可以提供干细胞。这些研究将为未来的开发和应用提供科学依据。
