Pasqualitto Filippo, Panin Francesca, Maidhof Clemens, Thompson Naomi, Fachner Jörg
Cambridge Institute for Music Therapy Research, Anglia Ruskin University, Cambridge CB1 1PT, UK.
School of Life Sciences, Faculty of Science and Engineering, Anglia Ruskin University, Cambridge CB1 1PT, UK.
Brain Sci. 2023 Feb 3;13(2):259. doi: 10.3390/brainsci13020259.
Recent findings indicate that Music Therapy (MT) and Music-Based Interventions (MBIs) may reduce craving symptoms in people with Substance Use Disorders (SUD). However, MT/MBIs can lead SUD clients to recall memories associated with their drug history and the corresponding strong emotions (addiction memories). Craving is a central component of SUD, possibly linked to relapse and triggered by several factors such as the recall of memories associated with the drug experience. Therefore, to address the topic of what elements can account for an improvement in craving symptoms after MT/MBIs, we conducted a narrative review that (1) describes the brain correlates of emotionally salient autobiographical memories evoked by music, (2) outlines neuroimaging and neurophysiological studies suggesting how the experience of craving may encompass the recall of emotionally filled moments, and (3) points out the role of perineuronal nets (PNNs) in addiction memory neuroplasticity. We highlight how autobiographical memory retrieval, music-evoked autobiographical memories, and craving share similar neural activations with PNNs which represent a causal element in the processing of addiction memory. We finally conclude by considering how the neuroplastic characteristics of addiction memory might represent the ground to update and/or recalibrate, within the therapy, the emotional content related to the recall.
最近的研究结果表明，音乐疗法（MT）和基于音乐的干预措施（MBIs）可能会减轻物质使用障碍（SUD）患者的渴望症状。然而，MT/MBIs可能会导致SUD患者回忆起与他们吸毒史相关的记忆以及相应的强烈情绪（成瘾记忆）。渴望是SUD的一个核心组成部分，可能与复发有关，并由多种因素触发，如回忆与吸毒经历相关的记忆。因此，为了探讨哪些因素可以解释MT/MBIs后渴望症状的改善，我们进行了一项叙述性综述，该综述（1）描述了音乐唤起的情感突出的自传体记忆的大脑相关性，（2）概述了神经影像学和神经生理学研究，这些研究表明渴望的体验可能如何包括对充满情感时刻的回忆，以及（3）指出神经周网（PNNs）在成瘾记忆神经可塑性中的作用。我们强调自传体记忆检索、音乐唤起的自传体记忆和渴望如何与PNNs共享相似的神经激活，而PNNs在成瘾记忆处理中代表一个因果因素。我们最后通过考虑成瘾记忆的神经可塑性特征如何可能成为在治疗中更新和/或重新校准与回忆相关的情感内容的基础来得出结论。
