Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Port-Said University, Port Said 42526, Egypt.
Biosensors (Basel). 2023 Feb 8;13(2):243. doi: 10.3390/bios13020243.
An innovative polymer-based electro-sensor decorated with Tb nanoparticles has been developed for the first time. The fabricated sensor was utilized for trace determination of favipiravir (FAV), a recently US FDA-approved antiviral drug for the treatment of COVID-19. Different techniques, including ultraviolet-visible spectrophotometry (UV-VIS), cyclic voltammetry (CV), scanning electron microscope (SEM), X-ray Diffraction (XRD) and electrochemical impedance spectroscopy (EIS), were applied for the characterization of the developed electrode Tb@ poly m-THB/PGE. Various experimental variables, including pH, potential range, polymer concentration, number of cycles, scan rate and deposition time, were optimized. Moreover, different voltammetric parameters were examined and optimized. The presented SWV method showed linearity over the range of 10-150 × 10 M with a good correlation coefficient (R = 0.9994), and the detection limit (LOD) reached 3.1 × 10 M. The proposed method was applied for the quantification of FAV in tablet dosage forms and in human plasma without any interference from complex matrices, obtaining good % recovery results (98.58-101.93%).
首次开发了一种基于聚合物的新型电传感器，该传感器用 Tb 纳米粒子进行了修饰。所制备的传感器用于痕量测定法匹拉韦（FAV），FAV 是最近获得美国 FDA 批准的用于治疗 COVID-19 的抗病毒药物。应用包括紫外-可见分光光度法（UV-VIS）、循环伏安法（CV）、扫描电子显微镜（SEM）、X 射线衍射（XRD）和电化学阻抗谱（EIS）在内的不同技术对所开发的 Tb@poly m-THB/PGE 电极进行了表征。优化了各种实验变量，包括 pH 值、电位范围、聚合物浓度、循环次数、扫描速率和沉积时间。此外，还检查和优化了不同的伏安参数。所提出的 SWV 方法在 10-150×10 M 的范围内表现出良好的线性关系，相关系数（R = 0.9994）较高，检测限（LOD）达到 3.1×10 M。该方法可用于片剂剂型和人血浆中 FAV 的定量分析，无需复杂基质的干扰，获得了良好的%回收率结果（98.58-101.93%）。
Zotero 插件
