Mohamed Mona A, Eldin Ghada M G, Ismail Sani M, Zine Nadia, Elaissari Abdelhamid, Jaffrezic-Renault Nicole, Errachid Abdelhamid
Pharmaceutical Chemistry Department, National Organization for Drug Control and Research, Egyptian Drug Authority, Giza, Egypt.
Institut de Sciences Analytiques (ISA)-UMR 5280, Université Claude Bernard Lyon 1, 5 rue de la doua, 69100 Lyon, France.
J Electroanal Chem (Lausanne). 2021 Aug 15;895:115422. doi: 10.1016/j.jelechem.2021.115422. Epub 2021 May 28.
Due the current pandemic of COVID-19, an urgent need is required for serious medical treatments of a huge number of patients. The world health organization (WHO) approved Favipiravir (FAV) as a medication for patients infected with corona virus. In the current study, we report the first simple electrochemical, greatly sensitive sensor using MnO-rGO nanocomposite for the accurate determination of Favipiravir (FAV). The developed sensor showed a high improvement in the electrochemical oxidation of FAV comparing to the unmodified screen-printed electrode (SPE). The suggested platform constituents and the electrochemical measurements parameters were studied. Under optimal experimental parameters, a current response to the concentration change of FAV was found to be in the linear range of 1.0 × 10-5.5 × 10 M at pH 7.0 with a limit of detection 0.11 µM and a quantification limit of 0.33 µM. The developed platform was confirmed by the precise analysis of FAV in real samples including dosage form and plasma. The developed platform can be applied in different fields of industry quality control and clinical analysis laboratories for the FAV determination.
由于当前新冠疫情大流行，大量患者急需有效的医疗救治。世界卫生组织（WHO）批准法匹拉韦（FAV）作为治疗冠状病毒感染患者的药物。在本研究中，我们报道了首个使用MnO-rGO纳米复合材料的简单、高灵敏度电化学传感器，用于准确测定法匹拉韦（FAV）。与未修饰的丝网印刷电极（SPE）相比，所开发的传感器在FAV的电化学氧化方面有显著改善。研究了所建议的平台组成和电化学测量参数。在最佳实验参数下，发现在pH 7.0时，FAV浓度变化的电流响应在1.0×10⁻⁵ - 5.5×10⁻⁵ M的线性范围内，检测限为0.11 μM，定量限为0.33 μM。通过对包括剂型和血浆在内的实际样品中FAV的精确分析，证实了所开发的平台。所开发的平台可应用于工业质量控制和临床分析实验室的不同领域，用于FAV的测定。
