Department of Epidemiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Department of Kinesiology, The University of Alabama, Tuscaloosa, AL 35487, USA.
Int J Environ Res Public Health. 2023 Feb 17;20(4):3555. doi: 10.3390/ijerph20043555.
This study examined the acute effects of high-intensity resistance exercise with blood flow restriction (BFR) on performance and fatigue, metabolic stress, and markers of inflammation (interleukin-6 (IL-6)), muscle damage (myoglobin), angiogenesis (vascular endothelial growth factor (VEGF)). Thirteen resistance-trained participants (four female, 24.8 ± 4.7 years) performed four sets of barbell back-squats (75% 1RM) to failure under two conditions: blood flow restriction (BFR, bilateral 80% occlusion pressure) and control (CTRL). Completed repetitions and pre-post-exercise changes in maximal voluntary isometric contractions, countermovement jump, barbell mean propulsive velocity, and surface electromyography were recorded. Pre-post blood lactate (BLa) and venous blood samples for analysis of IL-6, myoglobin, and VEGF were collected. Ratings of perceived exertion (RPE) and pain were recorded for each set. Fewer repetitions were performed during BFR (25.5 ± 9.6 reps) compared to CTRL (43.4 ± 14.2 reps, < 0.001), with greater repetitions performed during sets 1, 2, and 4 ( < 0.05) in CTRL. Although RPE between conditions was similar across all sets ( > 0.05), pain was greater in BFR across all sets ( < 0.05). Post-exercise fatigue was comparable between conditions. BLa was significantly greater in CTRL compared to BFR at two minutes ( = 0.001) but not four minutes post-exercise ( = 0.063). IL-6 was significantly elevated following BFR ( = 0.011). Comparable increases in myoglobin ( > 0.05) and no changes in VEGF were observed ( > 0.05). BFR increases the rate of muscular fatigue during high-intensity resistance exercise and acutely enhances IL-6 response, with significantly less total work performed, but increases pain perception, limiting implementation.
本研究旨在探讨在血流限制（BFR）条件下进行高强度抗阻运动对运动表现和疲劳、代谢应激以及炎症标志物（白细胞介素 6（IL-6））、肌肉损伤（肌红蛋白）、血管生成（血管内皮生长因子（VEGF））的急性影响。13 名有抗阻训练经验的参与者（4 名女性，24.8±4.7 岁）在两种条件下完成了 4 组杠铃深蹲（75% 1RM 至力竭）：血流限制（BFR，双侧 80%闭塞压力）和对照（CTRL）。记录了完成的重复次数和最大自主等长收缩、反跳跳、杠铃平均推进速度以及表面肌电图的前后变化。采集了血乳酸（BLa）和静脉血样，用于分析 IL-6、肌红蛋白和 VEGF。为每组记录了主观用力等级（RPE）和疼痛评分。与 CTRL（43.4±14.2 次，<0.001）相比，BFR 时的重复次数更少（25.5±9.6 次），在 CTRL 中，第 1、2 和 4 组的重复次数更多（<0.05）。尽管在所有组中，RPE 在两种条件之间相似（>0.05），但在所有组中，BFR 时的疼痛更大（<0.05）。运动后疲劳在两种条件之间相当。与 BFR 相比，CTRL 在两分钟时的 BLa 显著更高（=0.001），但在四分钟时无差异（=0.063）。BFR 后 IL-6 显著升高（=0.011）。肌红蛋白（>0.05）观察到类似的增加，而 VEGF 没有变化（>0.05）。BFR 增加了高强度抗阻运动过程中肌肉疲劳的速度，并急性增强了 IL-6 反应，尽管总工作量减少，但增加了疼痛感知，限制了实施。
