Center of Excellence in Osteoarthritis and Musculoskeleton, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Center of Excellence in Biomechanics and Innovative Spine Surgery, Department of Orthopaedics, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand.
Int J Mol Sci. 2023 Feb 5;24(4):3152. doi: 10.3390/ijms24043152.
Lumbar disc degeneration (LDD) is one of the fundamental causes of low back pain. The aims of this study were to determine serum 25-hydroxyvitamin D (25(OH)D) levels and physical performance and to investigate the relationship between serum vitamin D levels, muscle strength and physical activity in elderly patients with LDD. The participants were 200 LDD patients, including 155 females and 45 males aged 60 years and over. Data on body mass index and body composition were collected. Serum 25(OH)D and parathyroid hormone levels were measured. Serum 25(OH)D was classified into the insufficiency group: <30 ng/mL and the sufficiency group: ≥30 ng/mL. Muscle strength was assessed by grip strength, and physical performance (short physical performance battery) was evaluated by the balance test, chair stand test, gait speed, and Timed Up and Go (TUG) test. Serum 25(OH)D levels in LDD patients with vitamin D insufficiency were significantly lower than in those with vitamin D sufficiency ( < 0.0001). LDD patients with vitamin D insufficiency had a prolonged time in physical performance on gait speed ( = 0.008), chair stand test ( = 0.013), and TUG test ( = 0.014) compared to those with vitamin D sufficiency. Additionally, we found that serum 25(OH)D levels were significantly correlated with gait speed ( = -0.153, = 0.03) and TUG test ( = -0.168, = 0.017) in LDD patients. No significant associations with serum 25(OH)D status were observed for grip strength and balance tests among patients. These findings demonstrate that higher serum 25(OH)D levels are associated with better physical performance in LDD patients.
腰椎间盘退变（LDD）是腰痛的基本原因之一。本研究旨在确定血清 25-羟维生素 D（25（OH）D）水平和身体机能，并探讨老年 LDD 患者血清维生素 D 水平、肌肉力量与身体活动之间的关系。研究对象为 200 例 LDD 患者，其中女性 155 例，男性 45 例，年龄均在 60 岁以上。收集了体重指数和身体成分数据。测量了血清 25（OH）D 和甲状旁腺激素水平。将血清 25（OH）D 分为不足组：<30ng/mL 和充足组：≥30ng/mL。肌肉力量通过握力评估，身体机能（简易体能测试）通过平衡测试、坐立测试、步态速度和计时起立行走测试（TUG）评估。维生素 D 不足的 LDD 患者的血清 25（OH）D 水平明显低于维生素 D 充足的患者（<0.0001）。与维生素 D 充足的患者相比，维生素 D 不足的 LDD 患者在步态速度（ = 0.008）、坐立测试（ = 0.013）和 TUG 测试（ = 0.014）上的身体机能表现时间更长。此外，我们发现血清 25（OH）D 水平与 LDD 患者的步态速度（ = -0.153， = 0.03）和 TUG 测试（ = -0.168， = 0.017）呈显著负相关。在患者中，血清 25（OH）D 状态与握力和平衡测试无显著相关性。这些发现表明，血清 25（OH）D 水平较高与 LDD 患者的身体机能更好相关。
