Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Chin J Integr Med. 2024 May;30(5):458-467. doi: 10.1007/s11655-023-3649-5. Epub 2023 Sep 26.
Although there have been significant advances in the treatment of heart failure in recent years, chronic heart failure remains a leading cause of cardiovascular disease-related death. Many studies have found that targeted cardiac metabolic remodeling has good potential for the treatment of heart failure. However, most of the drugs that increase cardiac energy are still in the theoretical or testing stage. Some research has found that botanical drugs not only increase myocardial energy metabolism through multiple targets but also have the potential to restore the balance of myocardial substrate metabolism. In this review, we summarized the mechanisms by which botanical drugs (the active ingredients/formulas/Chinese patent medicines) improve substrate utilization and promote myocardial energy metabolism by activating AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptors (PPARs) and other related targets. At the same time, some potential protective effects of botanical drugs on myocardium, such as alleviating oxidative stress and dysbiosis signaling, caused by metabolic disorders, were briefly discussed.
尽管近年来心力衰竭的治疗取得了重大进展，但慢性心力衰竭仍然是心血管疾病相关死亡的主要原因。许多研究发现，靶向心脏代谢重构对心力衰竭的治疗具有良好的潜力。然而，大多数增加心脏能量的药物仍处于理论或测试阶段。一些研究发现，植物药不仅通过多个靶点增加心肌能量代谢，而且具有恢复心肌底物代谢平衡的潜力。在这篇综述中，我们总结了植物药（活性成分/配方/中药）通过激活 AMP 激活的蛋白激酶（AMPK）、过氧化物酶体增殖物激活受体（PPARs）和其他相关靶点来改善底物利用和促进心肌能量代谢的机制。同时，简要讨论了植物药对代谢紊乱引起的心肌氧化应激和失调信号等潜在的保护作用。
