Siesky Brent, Harris Alon, Verticchio Vercellin Alice, Arciero Julia, Fry Brendan, Eckert George, Guidoboni Giovanna, Oddone Francesco, Antman Gal
Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Department of Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
J Clin Med. 2023 Feb 6;12(4):1287. doi: 10.3390/jcm12041287.
This study investigated the heterogeneity of ocular hemodynamic biomarkers in early open angle glaucoma (OAG) patients and healthy controls of African (AD) and European descent (ED). Sixty OAG patients (38 ED, 22 AD) and 65 healthy controls (47 ED, 18 AD) participated in a prospective, cross-sectional study assessing: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), visual field (VF) and vascular densities (VD) via optical coherence tomography angiography (OCTA). Comparisons between outcomes were adjusted for age, diabetes status and BP. VF, IOP, BP and OPP were not significantly different between OAG subgroups or controls. Multiple VD biomarkers were significantly lower in OAG patients of ED ( < 0.05) while central macular VD was lower in OAG patients of AD vs. OAG patients of ED ( = 0.024). Macular and parafoveal thickness were significantly lower in AD OAG patients compared to those of ED ( = 0.006-0.049). OAG patients of AD had a negative correlation between IOP and VF index (r = -0.86) while ED patients had a slightly positive relationship (r = 0.26); difference between groups ( < 0.001). Age-adjusted OCTA biomarkers exhibit significant variation in early OAG patients of AD and ED.
本研究调查了非洲裔（AD）和欧洲裔（ED）早期开角型青光眼（OAG）患者及健康对照者眼部血流动力学生物标志物的异质性。60例OAG患者（38例ED，22例AD）和65例健康对照者（47例ED，18例AD）参与了一项前瞻性横断面研究，评估指标包括：眼压（IOP）、血压（BP）、眼灌注压（OPP）、视野（VF）以及通过光学相干断层扫描血管造影（OCTA）测量的血管密度（VD）。对各结果之间的比较进行了年龄、糖尿病状态和血压的校正。OAG亚组或对照组之间的VF、IOP、BP和OPP无显著差异。ED的OAG患者中多种VD生物标志物显著降低（<0.05），而AD的OAG患者中央黄斑VD低于ED的OAG患者（=0.024）。与ED的OAG患者相比，AD的OAG患者黄斑和黄斑旁厚度显著降低（=0.006 - 0.049）。AD的OAG患者IOP与VF指数呈负相关（r = -0.86），而ED患者呈轻度正相关（r = 0.26）；组间差异（<0.001）。年龄校正后的OCTA生物标志物在AD和ED的早期OAG患者中表现出显著差异。
