USC Roski Eye Institute, Keck Medicine of University of Southern California, Los Angeles, California, USA.
Southern California Eyecare and Vision Research Institute, Los Angeles, California, USA.
Am J Ophthalmol. 2019 Nov;207:240-247. doi: 10.1016/j.ajo.2019.06.014. Epub 2019 Jun 21.
To determine the relationship between systemic factors and radial peripapillary capillary (RPC) vessel density (VD) in healthy African American (AA) participants of the African American Eye Disease Study.
A population-based, cross-sectional study.
A total of 4135 eyes from 2127 AA participants aged 40 years and older in Inglewood, California, were imaged for 6×6-mm optic disc scans on a spectral-domain optical coherence tomography angiography (OCTA) device. Of these, 1029 eyes from 1029 participants who met the inclusion and exclusion criteria were analyzed, including only 1 eye per participant. Custom software was used to quantify RPC VD. Multivariate linear regression was used to identify systemic factors associated with RPC VD with a significance level set at 0.05. The contribution of each variable to the final model was estimated with the magnitude of standardized regression coefficients (SRCs). The fit of the final model was measured by R.
The average RPC VD was 0.346±0.045. Controlling for signal strength, the systemic variables in the final multivariate model associated with reduced RPC VD were older age (β = -0.0123 per decade; SRC = -0.2733; P < .0001), male sex (β = -0.0067; SRC = -0.0716; P = .0060), and longer diabetes duration (β = -0.0022 per 5 years; SRC = -0.0527; P = .0427). The model R was 0.3689.
Age, sex, and systemic influences, such as diabetes duration, need to be considered when assessing changes in RPC VD in glaucoma and other ocular diseases. Longitudinal studies are needed to investigate whether reduced RPC VD and the factors that affect it are associated with an increased risk of developing glaucomatous nerve damage.
确定系统性因素与健康非裔美国人（AA）参与者的视盘旁放射状毛细血管（RPC）血管密度（VD）之间的关系。
基于人群的横断面研究。
对加利福尼亚州英格尔伍德的 4135 只眼睛（来自 2127 名年龄在 40 岁及以上的 AA 参与者）进行 6×6mm 视盘扫描的光谱域光相干断层扫描血管造影（OCTA）成像。其中，符合纳入和排除标准的 1029 名参与者的 1029 只眼睛进行了分析，每个参与者仅分析了 1 只眼睛。使用定制软件来量化 RPC VD。采用多元线性回归来确定与 RPC VD 相关的系统性因素，显著性水平设为 0.05。使用标准化回归系数（SRC）的大小来估计每个变量对最终模型的贡献。通过 R 来衡量最终模型的拟合度。
平均 RPC VD 为 0.346±0.045。在校正信号强度后，最终多元模型中与 RPC VD 降低相关的系统性变量为年龄较大（每十年减少 0.0123；SRC = -0.2733；P <.0001）、男性（β = -0.0067；SRC = -0.0716；P =.0060）和糖尿病病程较长（每 5 年减少 0.0022；SRC = -0.0527；P =.0427）。模型 R 为 0.3689。
在评估青光眼和其他眼部疾病中 RPC VD 的变化时，需要考虑年龄、性别以及糖尿病病程等系统性因素。需要进行纵向研究，以调查 RPC VD 降低及其影响因素是否与发生青光眼性神经损伤的风险增加有关。
