Chávez-Ocaña Sonia Del Carmen, Bravata-Alcántara Juan Carlos, Cortés-Ortiz Iliana Alejandra, Reyes-Sandoval Arturo, García-Machorro Jazmín, Herrera-Gonzalez Norma Estela
Genetics and Molecular Diagnosis Laboratory, Juárez de Mexico Hospital, Mexico City 07760, Mexico.
Molecular Oncology Lab, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Col. Casco de Santo Tomás, Ciudad de México 11340, Mexico.
J Clin Med. 2023 Feb 7;12(4):1323. doi: 10.3390/jcm12041323.
Manifestations of COVID-19 are diverse and range from asymptomatic to severe, critical illness and death. Cases requiring hospital care (in severe and critical illnesses) are associated with comorbidities and hyperactivation of the immune system. Therefore, in this exploratory observational study, we analyzed which parameters are associated with mortality. We evaluated: demographic characteristics (age, sex and comorbidities), laboratory data (albumin, leukocytes, lymphocytes, platelets, ferritin), days of hospital stay, interleukins (IL-2, IL-6, IL-7, IL-10, IL-17) and sP-selectin in 40 Mexican patients admitted to medical emergencies with a confirmed diagnosis of COVID-19, a complete clinical record, and who signed the informed consent. Twenty severe (they required intermediate care with non-invasive ventilation) and twenty critically ill patients (they required mechanical ventilation) were classified, and these were subsequently compared with healthy and recovered subjects. A significant difference was found between the hospitalized groups in the parameters of age, ferritin, days of hospital stay and death with values = 0.0145, = 0.0441, = 0.0001 and = 0.0001, respectively. In the determination of cytokines and P-selectin, a significant difference was found between the following groups: recovered patients and healthy volunteers compared with hospitalized patients in severe and critical condition. Importantly, IL-7 remained elevated one year later in recovered patients. Taken together, these values determined at the time of hospital admission could be useful to monitor patients closely and evaluate in-hospital progress, hospital discharge, and out-of-hospital progress.
新型冠状病毒肺炎（COVID-19）的表现多种多样，从无症状到重症、危重症及死亡。需要住院治疗的病例（重症和危重症）与合并症及免疫系统过度激活有关。因此，在这项探索性观察研究中，我们分析了哪些参数与死亡率相关。我们评估了40名确诊为COVID-19、有完整临床记录且签署知情同意书的墨西哥医学急诊患者的人口统计学特征（年龄、性别和合并症）、实验室数据（白蛋白、白细胞、淋巴细胞、血小板、铁蛋白）、住院天数、白细胞介素（IL-2、IL-6、IL-7、IL-10、IL-17）和可溶性P选择素（sP-selectin）。对20名重症患者（需要无创通气的中级护理）和20名危重症患者（需要机械通气）进行了分类，随后将他们与健康及康复受试者进行比较。在住院组之间，年龄、铁蛋白、住院天数和死亡参数存在显著差异，其P值分别为0.0145、0.0441、0.0001和0.0001。在细胞因子和P选择素的测定中，在以下几组之间发现了显著差异：康复患者和健康志愿者与重症和危重症住院患者相比。重要的是，康复患者一年后IL-7仍保持升高。综上所述，入院时测定的这些数值可能有助于密切监测患者并评估住院进展、出院情况及院外进展。
